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The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.

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Title: The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Authors: Ng VH; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.; Program in Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA., Spencer Z; Department of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, 03755, USA., Neitzel LR; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Nayak A; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA., Loberg MA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Shen C; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA., Kassel SN; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Kroh HK; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., An Z; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94158, USA., Anthony CC; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Bryant JM; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Lawson A; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Goldsmith L; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Benchabane H; Department of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, 03755, USA., Hansen AG; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.; STEMCELL Technologies, 1618 Station Street, Vancouver, BC, V6A 1B6, Canada., Li J; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., D'Souza S; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Lebensohn AM; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Rohatgi R; Departments of Biochemistry, Stanford University School of Medicine, Stanford, CA, 94305, USA., Weiss WA; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94158, USA., Weiss VL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Williams C; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Hong CC; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Robbins DJ; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA., Ahmed Y; Department of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, 03755, USA. yashi.ahmed@dartmouth.edu., Lee E; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA. ethan.lee@vanderbilt.edu.; Program in Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA. ethan.lee@vanderbilt.edu.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. ethan.lee@vanderbilt.edu.
Source: Nature communications [Nat Commun] 2023 Oct 05; Vol. 14 (1), pp. 6173. Date of Electronic Publication: 2023 Oct 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
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  Data: <searchLink fieldCode="AU" term="%22Ng+VH%22">Ng VH</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.; Program in Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Spencer+Z%22">Spencer Z</searchLink>; Department of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, 03755, USA.<br /><searchLink fieldCode="AU" term="%22Neitzel+LR%22">Neitzel LR</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.<br /><searchLink fieldCode="AU" term="%22Nayak+A%22">Nayak A</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA.<br /><searchLink fieldCode="AU" term="%22Loberg+MA%22">Loberg MA</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Shen+C%22">Shen C</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA.<br /><searchLink fieldCode="AU" term="%22Kassel+SN%22">Kassel SN</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Kroh+HK%22">Kroh HK</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22An+Z%22">An Z</searchLink>; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Anthony+CC%22">Anthony CC</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Bryant+JM%22">Bryant JM</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Lawson+A%22">Lawson A</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Goldsmith+L%22">Goldsmith L</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Benchabane+H%22">Benchabane H</searchLink>; Department of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, 03755, USA.<br /><searchLink fieldCode="AU" term="%22Hansen+AG%22">Hansen AG</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.; STEMCELL Technologies, 1618 Station Street, Vancouver, BC, V6A 1B6, Canada.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22D'Souza+S%22">D'Souza S</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Lebensohn+AM%22">Lebensohn AM</searchLink>; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Rohatgi+R%22">Rohatgi R</searchLink>; Departments of Biochemistry, Stanford University School of Medicine, Stanford, CA, 94305, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+WA%22">Weiss WA</searchLink>; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+VL%22">Weiss VL</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Williams+C%22">Williams C</searchLink>; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.<br /><searchLink fieldCode="AU" term="%22Hong+CC%22">Hong CC</searchLink>; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+DJ%22">Robbins DJ</searchLink>; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA.<br /><searchLink fieldCode="AU" term="%22Ahmed+Y%22">Ahmed Y</searchLink>; Department of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, 03755, USA. yashi.ahmed@dartmouth.edu.<br /><searchLink fieldCode="AU" term="%22Lee+E%22">Lee E</searchLink>; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA. ethan.lee@vanderbilt.edu.; Program in Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA. ethan.lee@vanderbilt.edu.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. ethan.lee@vanderbilt.edu.
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