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Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion.

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Title: Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion.
Authors: Kellish PC; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Marsic D; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Crosson SM; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Choudhury S; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Scalabrino ML; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Strang CE; Department of Ophthalmology, University of Alabama at Birmingham, Birmingham AL 35294, USA., Hill J; Department of Ophthalmology, University of Alabama at Birmingham, Birmingham AL 35294, USA., McCullough KT; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Peterson JJ; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Fajardo D; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Gupte S; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Makal V; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Kondratov O; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Kondratova L; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Iyer S; Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA., Witherspoon CD; Department of Ophthalmology, University of Alabama at Birmingham, Birmingham AL 35294, USA., Gamlin PD; Department of Ophthalmology, University of Alabama at Birmingham, Birmingham AL 35294, USA., Zolotukhin S; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA., Boye SL; Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA., Boye SE; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA. Electronic address: shaire@ufl.edu.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2023 Dec 06; Vol. 31 (12), pp. 3441-3456. Date of Electronic Publication: 2023 Oct 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion.
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  Data: <searchLink fieldCode="AU" term="%22Kellish+PC%22">Kellish PC</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Marsic+D%22">Marsic D</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Crosson+SM%22">Crosson SM</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Choudhury+S%22">Choudhury S</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Scalabrino+ML%22">Scalabrino ML</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Strang+CE%22">Strang CE</searchLink>; Department of Ophthalmology, University of Alabama at Birmingham, Birmingham AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Hill+J%22">Hill J</searchLink>; Department of Ophthalmology, University of Alabama at Birmingham, Birmingham AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22McCullough+KT%22">McCullough KT</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Peterson+JJ%22">Peterson JJ</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Fajardo+D%22">Fajardo D</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Gupte+S%22">Gupte S</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Makal+V%22">Makal V</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Kondratov+O%22">Kondratov O</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Kondratova+L%22">Kondratova L</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Iyer+S%22">Iyer S</searchLink>; Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Witherspoon+CD%22">Witherspoon CD</searchLink>; Department of Ophthalmology, University of Alabama at Birmingham, Birmingham AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Gamlin+PD%22">Gamlin PD</searchLink>; Department of Ophthalmology, University of Alabama at Birmingham, Birmingham AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Zolotukhin+S%22">Zolotukhin S</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Boye+SL%22">Boye SL</searchLink>; Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Boye+SE%22">Boye SE</searchLink>; Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA. Electronic address: shaire@ufl.edu.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2023 Dec 06; Vol. 31 (12), pp. 3441-3456. <i>Date of Electronic Publication: </i>2023 Oct 09.
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