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MIJ821 (onfasprodil) in healthy volunteers: First-in-human, randomized, placebo-controlled study (single ascending dose and repeated intravenous dose).

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Title: MIJ821 (onfasprodil) in healthy volunteers: First-in-human, randomized, placebo-controlled study (single ascending dose and repeated intravenous dose).
Authors: Gomez-Mancilla B; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.; McGill University, Montreal, Québec, Canada., Levy JA; Seaview A Quotient, Miami, Florida, USA., Ganesan S; Novartis Healthcare Pvt. Ltd., Hyderabad, India., Faller T; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Issachar G; Elminda Ltd., Herzliya, Israel., Peremen Z; Elminda Ltd., Herzliya, Israel., Laufer O; Elminda Ltd., Herzliya, Israel., Shani-Hershkovich R; Elminda Ltd., Herzliya, Israel., Biliouris K; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Walker E; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Healy MP; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Sverdlov O; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA., Desai S; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA., Ghaemi SN; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.; Tufts Medical Center, Tufts University, Boston, Massachusetts, USA., Cha JH; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Shanker YG; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.; Beam Therapeutics, Cambridge, Massachusetts, USA.
Source: Clinical and translational science [Clin Transl Sci] 2023 Nov; Vol. 16 (11), pp. 2236-2252. Date of Electronic Publication: 2023 Oct 10.
Publication Type: Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MIJ821 (onfasprodil) in healthy volunteers: First-in-human, randomized, placebo-controlled study (single ascending dose and repeated intravenous dose).
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  Data: <searchLink fieldCode="AU" term="%22Gomez-Mancilla+B%22">Gomez-Mancilla B</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.; McGill University, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Levy+JA%22">Levy JA</searchLink>; Seaview A Quotient, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Ganesan+S%22">Ganesan S</searchLink>; Novartis Healthcare Pvt. Ltd., Hyderabad, India.<br /><searchLink fieldCode="AU" term="%22Faller+T%22">Faller T</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Issachar+G%22">Issachar G</searchLink>; Elminda Ltd., Herzliya, Israel.<br /><searchLink fieldCode="AU" term="%22Peremen+Z%22">Peremen Z</searchLink>; Elminda Ltd., Herzliya, Israel.<br /><searchLink fieldCode="AU" term="%22Laufer+O%22">Laufer O</searchLink>; Elminda Ltd., Herzliya, Israel.<br /><searchLink fieldCode="AU" term="%22Shani-Hershkovich+R%22">Shani-Hershkovich R</searchLink>; Elminda Ltd., Herzliya, Israel.<br /><searchLink fieldCode="AU" term="%22Biliouris+K%22">Biliouris K</searchLink>; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Walker+E%22">Walker E</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Healy+MP%22">Healy MP</searchLink>; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sverdlov+O%22">Sverdlov O</searchLink>; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Desai+S%22">Desai S</searchLink>; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Ghaemi+SN%22">Ghaemi SN</searchLink>; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.; Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cha+JH%22">Cha JH</searchLink>; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Shanker+YG%22">Shanker YG</searchLink>; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.; Beam Therapeutics, Cambridge, Massachusetts, USA.
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  Data: <searchLink fieldCode="JN" term="%22101474067%22">Clinical and translational science</searchLink> [Clin Transl Sci] 2023 Nov; Vol. 16 (11), pp. 2236-2252. <i>Date of Electronic Publication: </i>2023 Oct 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22WileyBlackwell+Pub%22">WileyBlackwell Pub </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101474067 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1752-8062 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217528054%22">17528054 </searchLink><i>NLM ISO Abbreviation: </i>Clin Transl Sci <i>Subsets: </i>MEDLINE
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