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Apoptotic stress causes mtDNA release during senescence and drives the SASP.

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Title: Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Authors: Victorelli S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Salmonowicz H; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Biosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.; ReMedy International Research Agenda Unit, IMol Polish Academy of Sciences, Warsaw, Poland., Chapman J; Biosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK., Martini H; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Vizioli MG; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Riley JS; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Institute of Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria., Cloix C; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Hall-Younger E; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Machado Espindola-Netto J; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Jurk D; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Lagnado AB; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Sales Gomez L; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Farr JN; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Saul D; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Reed R; Biosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK., Kelly G; Biosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK., Eppard M; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Greaves LC; Wellcome Centre for Mitochondrial Research, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Dou Z; Center for Regenerative Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Pirius N; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Szczepanowska K; ReMedy International Research Agenda Unit, IMol Polish Academy of Sciences, Warsaw, Poland., Porritt RA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Huang H; Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Huang TY; Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Mann DA; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul, Turkey., Masuda CA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Dai H; Division of Oncology Research and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Kaufmann SH; Division of Oncology Research and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Zacharioudakis E; Department of Biochemistry, Department of Medicine, Montefiore Einstein Cancer Center, Wilf Family Cardiovascular Research Institute, Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA., Gavathiotis E; Department of Biochemistry, Department of Medicine, Montefiore Einstein Cancer Center, Wilf Family Cardiovascular Research Institute, Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Lei X; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Sainz AG; Salk Institute for Biological Studies, La Jolla, CA, USA.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Korolchuk VI; Biosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK., Adams PD; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Shadel GS; Salk Institute for Biological Studies, La Jolla, CA, USA., Tait SWG; Cancer Research UK Scotland Institute, Glasgow, UK. Stephen.Tait@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Glasgow, UK. Stephen.Tait@glasgow.ac.uk., Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. passos.joao@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. passos.joao@mayo.edu.
Source: Nature [Nature] 2023 Oct; Vol. 622 (7983), pp. 627-636. Date of Electronic Publication: 2023 Oct 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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