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Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals.

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Title: Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals.
Authors: Zhang Y; Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Center for Blood Brain Barrier Research, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA., Sharma S; Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Center for Blood Brain Barrier Research, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA., Jonnalagadda S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.; UNMC Center for Drug Discovery, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA., Kumari S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.; UNMC Center for Drug Discovery, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA., Queen A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.; UNMC Center for Drug Discovery, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA., Esfahani SH; Department of Foundational Medical Studies, William Beaumont School of Medicine, Oakland University, Rochester, MI, 48309, USA.; Laboratory for Neurodegenerative Disease & Drug Discovery, William Beaumont School of Medicine, Oakland University, Rochester, MI, 48309, USA., Archie SR; Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Center for Blood Brain Barrier Research, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA., Nozohouri S; Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Center for Blood Brain Barrier Research, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA., Patel D; Office of Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA., Trippier PC; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.; UNMC Center for Drug Discovery, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA., Karamyan VT; Department of Foundational Medical Studies, William Beaumont School of Medicine, Oakland University, Rochester, MI, 48309, USA.; Laboratory for Neurodegenerative Disease & Drug Discovery, William Beaumont School of Medicine, Oakland University, Rochester, MI, 48309, USA., Abbruscato TJ; Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA. Thomas.abbruscato@ttuhsc.edu.; Center for Blood Brain Barrier Research, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA. Thomas.abbruscato@ttuhsc.edu.
Source: Pharmaceutical research [Pharm Res] 2023 Nov; Vol. 40 (11), pp. 2747-2758. Date of Electronic Publication: 2023 Oct 13.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE
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  Data: Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Center for Blood Brain Barrier Research, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Center for Blood Brain Barrier Research, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.<br /><searchLink fieldCode="AU" term="%22Jonnalagadda+S%22">Jonnalagadda S</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.; UNMC Center for Drug Discovery, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.<br /><searchLink fieldCode="AU" term="%22Kumari+S%22">Kumari S</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.; UNMC Center for Drug Discovery, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.<br /><searchLink fieldCode="AU" term="%22Queen+A%22">Queen A</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.; UNMC Center for Drug Discovery, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.<br /><searchLink fieldCode="AU" term="%22Esfahani+SH%22">Esfahani SH</searchLink>; Department of Foundational Medical Studies, William Beaumont School of Medicine, Oakland University, Rochester, MI, 48309, USA.; Laboratory for Neurodegenerative Disease & Drug Discovery, William Beaumont School of Medicine, Oakland University, Rochester, MI, 48309, USA.<br /><searchLink fieldCode="AU" term="%22Archie+SR%22">Archie SR</searchLink>; Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Center for Blood Brain Barrier Research, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.<br /><searchLink fieldCode="AU" term="%22Nozohouri+S%22">Nozohouri S</searchLink>; Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Center for Blood Brain Barrier Research, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.<br /><searchLink fieldCode="AU" term="%22Patel+D%22">Patel D</searchLink>; Office of Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.<br /><searchLink fieldCode="AU" term="%22Trippier+PC%22">Trippier PC</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.; UNMC Center for Drug Discovery, University of Nebraska Medical Center (UNMC), Omaha, NE, 68106, USA.<br /><searchLink fieldCode="AU" term="%22Karamyan+VT%22">Karamyan VT</searchLink>; Department of Foundational Medical Studies, William Beaumont School of Medicine, Oakland University, Rochester, MI, 48309, USA.; Laboratory for Neurodegenerative Disease & Drug Discovery, William Beaumont School of Medicine, Oakland University, Rochester, MI, 48309, USA.<br /><searchLink fieldCode="AU" term="%22Abbruscato+TJ%22">Abbruscato TJ</searchLink>; Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA. Thomas.abbruscato@ttuhsc.edu.; Center for Blood Brain Barrier Research, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA. Thomas.abbruscato@ttuhsc.edu.
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        Value: 10.1007/s11095-023-03619-5
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