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Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice.

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Title: Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice.
Authors: O' Donovan DH; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom. Electronic address: daniel.odonovan1@astrazeneca.com., Baker D; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Ciotta G; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Degorce SL; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Demanze S; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Dockerill M; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Escudero-Ibarz L; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Ireland L; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Mao Y; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Packer MJ; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Robinson J; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Scarfe G; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Tang H; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Valge-Archer V; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Nov 15; Vol. 96, pp. 129518. Date of Electronic Publication: 2023 Oct 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 37838344
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice.
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  Data: <searchLink fieldCode="AU" term="%22O'+Donovan+DH%22">O' Donovan DH</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom. Electronic address: daniel.odonovan1@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ciotta+G%22">Ciotta G</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Degorce+SL%22">Degorce SL</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Demanze+S%22">Demanze S</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dockerill+M%22">Dockerill M</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Escudero-Ibarz+L%22">Escudero-Ibarz L</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ireland+L%22">Ireland L</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mao+Y%22">Mao Y</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Packer+MJ%22">Packer MJ</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Robinson+J%22">Robinson J</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Scarfe+G%22">Scarfe G</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tang+H%22">Tang H</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Valge-Archer+V%22">Valge-Archer V</searchLink>; Oncology R&D and Discovery Sciences, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.
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