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Structure of LRRK1 and mechanisms of autoinhibition and activation.

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Title: Structure of LRRK1 and mechanisms of autoinhibition and activation.
Authors: Reimer JM; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Dickey AM; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Lin YX; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Abrisch RG; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Mathea S; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Institute of Pharmaceutical Chemistry, Goethe-Universität, Frankfurt, Germany.; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe-Universität, Frankfurt, Germany., Chatterjee D; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Institute of Pharmaceutical Chemistry, Goethe-Universität, Frankfurt, Germany.; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe-Universität, Frankfurt, Germany., Fay EJ; Department of Molecular Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA., Knapp S; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Institute of Pharmaceutical Chemistry, Goethe-Universität, Frankfurt, Germany.; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe-Universität, Frankfurt, Germany., Daugherty MD; Department of Molecular Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA., Reck-Peterson SL; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. sreckpeterson@health.ucsd.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. sreckpeterson@health.ucsd.edu.; Department of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA. sreckpeterson@health.ucsd.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. sreckpeterson@health.ucsd.edu., Leschziner AE; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. aleschziner@health.ucsd.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. aleschziner@health.ucsd.edu.; Department of Molecular Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA. aleschziner@health.ucsd.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2023 Nov; Vol. 30 (11), pp. 1735-1745. Date of Electronic Publication: 2023 Oct 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Reimer+JM%22">Reimer JM</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dickey+AM%22">Dickey AM</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lin+YX%22">Lin YX</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Abrisch+RG%22">Abrisch RG</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mathea+S%22">Mathea S</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Institute of Pharmaceutical Chemistry, Goethe-Universität, Frankfurt, Germany.; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe-Universität, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Chatterjee+D%22">Chatterjee D</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Institute of Pharmaceutical Chemistry, Goethe-Universität, Frankfurt, Germany.; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe-Universität, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Fay+EJ%22">Fay EJ</searchLink>; Department of Molecular Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Knapp+S%22">Knapp S</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Institute of Pharmaceutical Chemistry, Goethe-Universität, Frankfurt, Germany.; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe-Universität, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Daugherty+MD%22">Daugherty MD</searchLink>; Department of Molecular Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Reck-Peterson+SL%22">Reck-Peterson SL</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. sreckpeterson@health.ucsd.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. sreckpeterson@health.ucsd.edu.; Department of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA. sreckpeterson@health.ucsd.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. sreckpeterson@health.ucsd.edu.<br /><searchLink fieldCode="AU" term="%22Leschziner+AE%22">Leschziner AE</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. aleschziner@health.ucsd.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. aleschziner@health.ucsd.edu.; Department of Molecular Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA. aleschziner@health.ucsd.edu.
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