ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial.
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| Title: | ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial. |
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| Authors: | Rossios C; Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom., Bashir T; Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom., Achison M; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom., Adamson S; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom., Akpan A; University of Liverpool, Liverpool University Hospitals NHS FT Trust, Clinical Research Network Northwest Coast, Liverpool, United Kingdom., Aspray T; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom., Avenell A; Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom., Band MM; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom., Burton LA; Medicine for the Elderly, NHS Tayside, Dundee, United Kingdom.; Ageing and Health, University of Dundee, Dundee, United Kingdom., Cvoro V; Victoria Hospital, Kirkcaldy, United Kingdom.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom., Donnan PT; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, United Kingdom., Duncan GW; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Medicine for the Elderly, NHS Lothian, Edinburgh, United Kingdom., George J; Dept Clinical Pharmacology, Division of Molecular & Clinical Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, United Kingdom., Gordon AL; Unit of Injury, Inflammation and Recovery, School of Medicine, University of Nottingham, Nottingham, United Kingdom.; NIHR Nottingham Biomedical Research Centre, Department of Medicine for the Elderly, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom., Gregson CL; Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; Older Person's Unit, Royal United Hospital NHS Foundation Trust Bath, Bath, United Kingdom., Hapca A; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom., Hume C; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom., Jackson TA; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom., Kerr S; Department of Older People's Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Kilgour A; Medicine for the Elderly, NHS Lothian, Edinburgh, United Kingdom.; Ageing and Health Research Group, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom., Masud T; Clinical Gerontology Research Unit, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, United Kingdom., McKenzie A; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom., McKenzie E; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom., Patel H; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHSFT, Southampton, Hampshire, United Kingdom., Pilvinyte K; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom., Roberts HC; Academic Geriatric Medicine, University of Southampton, Mailpoint 807 Southampton General Hospital, Southampton, United Kingdom., Sayer AA; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom., Smith KT; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom., Soiza RL; Ageing & Clinical Experimental Research (ACER) Group, University of Aberdeen, Aberdeen, United Kingdom., Steves CJ; Department of Twin Research and Genetic Epidemiology, King's College London & Department of Clinical Gerontology, King's College Hospital, London, United Kingdom., Struthers AD; Dept Clinical Pharmacology, Division of Molecular & Clinical Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, United Kingdom., Tiwari D; Bournemouth University and Royal Bournemouth Hospital, Bournemouth, United Kingdom., Whitney J; School of Population Health & Environmental Sciences, King's College London and King's College Hospital, London, United Kingdom., Witham MD; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom., Kemp PR; Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom. |
| Source: | PloS one [PLoS One] 2023 Oct 20; Vol. 18 (10), pp. e0292402. Date of Electronic Publication: 2023 Oct 20 (Print Publication: 2023). |
| Publication Type: | Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 37862321 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Rossios+C%22">Rossios C</searchLink>; Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bashir+T%22">Bashir T</searchLink>; Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Achison+M%22">Achison M</searchLink>; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Adamson+S%22">Adamson S</searchLink>; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Akpan+A%22">Akpan A</searchLink>; University of Liverpool, Liverpool University Hospitals NHS FT Trust, Clinical Research Network Northwest Coast, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Aspray+T%22">Aspray T</searchLink>; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Avenell+A%22">Avenell A</searchLink>; Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Band+MM%22">Band MM</searchLink>; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Burton+LA%22">Burton LA</searchLink>; Medicine for the Elderly, NHS Tayside, Dundee, United Kingdom.; Ageing and Health, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cvoro+V%22">Cvoro V</searchLink>; Victoria Hospital, Kirkcaldy, United Kingdom.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Donnan+PT%22">Donnan PT</searchLink>; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Duncan+GW%22">Duncan GW</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Medicine for the Elderly, NHS Lothian, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22George+J%22">George J</searchLink>; Dept Clinical Pharmacology, Division of Molecular & Clinical Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gordon+AL%22">Gordon AL</searchLink>; Unit of Injury, Inflammation and Recovery, School of Medicine, University of Nottingham, Nottingham, United Kingdom.; NIHR Nottingham Biomedical Research Centre, Department of Medicine for the Elderly, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gregson+CL%22">Gregson CL</searchLink>; Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; Older Person's Unit, Royal United Hospital NHS Foundation Trust Bath, Bath, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hapca+A%22">Hapca A</searchLink>; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hume+C%22">Hume C</searchLink>; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jackson+TA%22">Jackson TA</searchLink>; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kerr+S%22">Kerr S</searchLink>; Department of Older People's Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kilgour+A%22">Kilgour A</searchLink>; Medicine for the Elderly, NHS Lothian, Edinburgh, United Kingdom.; Ageing and Health Research Group, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Masud+T%22">Masud T</searchLink>; Clinical Gerontology Research Unit, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McKenzie+A%22">McKenzie A</searchLink>; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McKenzie+E%22">McKenzie E</searchLink>; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Patel+H%22">Patel H</searchLink>; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHSFT, Southampton, Hampshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pilvinyte+K%22">Pilvinyte K</searchLink>; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Roberts+HC%22">Roberts HC</searchLink>; Academic Geriatric Medicine, University of Southampton, Mailpoint 807 Southampton General Hospital, Southampton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sayer+AA%22">Sayer AA</searchLink>; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Smith+KT%22">Smith KT</searchLink>; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Soiza+RL%22">Soiza RL</searchLink>; Ageing & Clinical Experimental Research (ACER) Group, University of Aberdeen, Aberdeen, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Steves+CJ%22">Steves CJ</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London & Department of Clinical Gerontology, King's College Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Struthers+AD%22">Struthers AD</searchLink>; Dept Clinical Pharmacology, Division of Molecular & Clinical Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tiwari+D%22">Tiwari D</searchLink>; Bournemouth University and Royal Bournemouth Hospital, Bournemouth, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Whitney+J%22">Whitney J</searchLink>; School of Population Health & Environmental Sciences, King's College London and King's College Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Witham+MD%22">Witham MD</searchLink>; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kemp+PR%22">Kemp PR</searchLink>; Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2023 Oct 20; Vol. 18 (10), pp. e0292402. <i>Date of Electronic Publication: </i>2023 Oct 20 (<i>Print Publication: </i>2023). – Name: TypePub Label: Publication Type Group: TypPub Data: Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101285081 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1932-6203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219326203%22">19326203 </searchLink><i>NLM ISO Abbreviation: </i>PLoS One <i>Subsets: </i>MEDLINE |
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