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Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation.

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Title: Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation.
Authors: Bowen EE; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada; University of Manchester, Manchester M13 9PT, UK. Electronic address: emily.bowen@bristol.ac.uk., Hurcombe JA; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK., Barrington F; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK., Keir LS; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK., Farmer LK; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK., Wherlock MD; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK., Ortiz-Sandoval CG; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada., Bruno V; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada., Bohorquez-Hernandez A; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada., Diatlov D; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada., Rostam-Shirazi N; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada., Wells S; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire OX11 0RD, UK., Stewart M; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire OX11 0RD, UK., Teboul L; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire OX11 0RD, UK., Lay AC; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK; University of Manchester, Manchester M13 9PT, UK., Butler MJ; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK., Pope RJP; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK., Larkai EMS; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK., Morgan BP; UK Dementia Research Institute Cardiff and Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF144XN. UK., Moppett J; Bristol Royal Hospital for Sick Children, Bristol BS2 8BJ, UK., Satchell SC; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK., Welsh GI; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK., Walker PD; Arkana Laboratories, Little Rock, AZ 72211, USA., Licht C; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada., Saleem MA; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK; Bristol Royal Hospital for Sick Children, Bristol BS2 8BJ, UK., Coward RJM; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK; Bristol Royal Hospital for Sick Children, Bristol BS2 8BJ, UK. Electronic address: richard.coward@bristol.ac.uk.
Source: Med (New York, N.Y.) [Med] 2023 Nov 10; Vol. 4 (11), pp. 761-777.e8. Date of Electronic Publication: 2023 Oct 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769215 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-6340 (Electronic) Linking ISSN: 26666340 NLM ISO Abbreviation: Med Subsets: MEDLINE
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  Data: Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation.
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  Data: <searchLink fieldCode="AU" term="%22Bowen+EE%22">Bowen EE</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada; University of Manchester, Manchester M13 9PT, UK. Electronic address: emily.bowen@bristol.ac.uk.<br /><searchLink fieldCode="AU" term="%22Hurcombe+JA%22">Hurcombe JA</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK.<br /><searchLink fieldCode="AU" term="%22Barrington+F%22">Barrington F</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK.<br /><searchLink fieldCode="AU" term="%22Keir+LS%22">Keir LS</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK.<br /><searchLink fieldCode="AU" term="%22Farmer+LK%22">Farmer LK</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK.<br /><searchLink fieldCode="AU" term="%22Wherlock+MD%22">Wherlock MD</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK.<br /><searchLink fieldCode="AU" term="%22Ortiz-Sandoval+CG%22">Ortiz-Sandoval CG</searchLink>; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada.<br /><searchLink fieldCode="AU" term="%22Bruno+V%22">Bruno V</searchLink>; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada.<br /><searchLink fieldCode="AU" term="%22Bohorquez-Hernandez+A%22">Bohorquez-Hernandez A</searchLink>; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada.<br /><searchLink fieldCode="AU" term="%22Diatlov+D%22">Diatlov D</searchLink>; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada.<br /><searchLink fieldCode="AU" term="%22Rostam-Shirazi+N%22">Rostam-Shirazi N</searchLink>; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada.<br /><searchLink fieldCode="AU" term="%22Wells+S%22">Wells S</searchLink>; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire OX11 0RD, UK.<br /><searchLink fieldCode="AU" term="%22Stewart+M%22">Stewart M</searchLink>; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire OX11 0RD, UK.<br /><searchLink fieldCode="AU" term="%22Teboul+L%22">Teboul L</searchLink>; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire OX11 0RD, UK.<br /><searchLink fieldCode="AU" term="%22Lay+AC%22">Lay AC</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK; University of Manchester, Manchester M13 9PT, UK.<br /><searchLink fieldCode="AU" term="%22Butler+MJ%22">Butler MJ</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK.<br /><searchLink fieldCode="AU" term="%22Pope+RJP%22">Pope RJP</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK.<br /><searchLink fieldCode="AU" term="%22Larkai+EMS%22">Larkai EMS</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK.<br /><searchLink fieldCode="AU" term="%22Morgan+BP%22">Morgan BP</searchLink>; UK Dementia Research Institute Cardiff and Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF144XN. UK.<br /><searchLink fieldCode="AU" term="%22Moppett+J%22">Moppett J</searchLink>; Bristol Royal Hospital for Sick Children, Bristol BS2 8BJ, UK.<br /><searchLink fieldCode="AU" term="%22Satchell+SC%22">Satchell SC</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK.<br /><searchLink fieldCode="AU" term="%22Welsh+GI%22">Welsh GI</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK.<br /><searchLink fieldCode="AU" term="%22Walker+PD%22">Walker PD</searchLink>; Arkana Laboratories, Little Rock, AZ 72211, USA.<br /><searchLink fieldCode="AU" term="%22Licht+C%22">Licht C</searchLink>; The Hospital for Sick Children, Toronto, ON MG5 1X8, Canada.<br /><searchLink fieldCode="AU" term="%22Saleem+MA%22">Saleem MA</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK; Bristol Royal Hospital for Sick Children, Bristol BS2 8BJ, UK.<br /><searchLink fieldCode="AU" term="%22Coward+RJM%22">Coward RJM</searchLink>; Bristol Renal, Bristol Medical School, University of Bristol, Bristol BS1 3NY, UK; Bristol Royal Hospital for Sick Children, Bristol BS2 8BJ, UK. Electronic address: richard.coward@bristol.ac.uk.
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