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Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial.

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Title: Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial.
Authors: Kopczak A; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany., Stringer MS; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., van den Brink H; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands., Kerkhofs D; Department of Neurology and School for Cardiovascular Diseases, Maastricht University Medical Center+, Maastricht, Netherlands., Blair GW; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., van Dinther M; Department of Neurology and School for Cardiovascular Diseases, Maastricht University Medical Center+, Maastricht, Netherlands., Reyes CA; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Garcia DJ; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Onkenhout L; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands., Wartolowska KA; Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Thrippleton MJ; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Kampaite A; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Duering M; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany; Medical Image Analysis Center and Department of Biomedical Engineering, University of Basel, Basel, Switzerland., Staals J; Department of Neurology and School for Cardiovascular Diseases, Maastricht University Medical Center+, Maastricht, Netherlands., Lesnik-Oberstein S; Department of Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands., Muir KW; School of Psychology and Neuroscience, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK., Middeke M; Hypertoniezentrum München, Excellence Centre of the European Society of Hypertension, Munich, Germany., Norrving B; Department of Clinical Sciences Lund, Neurology, Skåne University Hospital, Lund University, Lund, Sweden., Bousser MG; Hôpital Lariboisière, APHP, Université Paris-Cité, Paris, France., Mansmann U; Institute for Medical Information Processing, Biometry, and Epidemiology, LMU Munich, Munich, Germany., Rothwell PM; Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Doubal FN; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., van Oostenbrugge R; Department of Neurology and School for Cardiovascular Diseases, Maastricht University Medical Center+, Maastricht, Netherlands., Biessels GJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands., Webb AJS; Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Wardlaw JM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Dichgans M; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany; German Center for Neurodegenerative Diseases, Munich, Germany; German Centre for Cardiovascular Research, Munich, Germany. Electronic address: martin.dichgans@med.uni-muenchen.de.
Corporate Authors: TREAT-SVDs collaborators
Source: The Lancet. Neurology [Lancet Neurol] 2023 Nov; Vol. 22 (11), pp. 991-1004.
Publication Type: Randomized Controlled Trial; Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE
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  Data: Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial.
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  Data: <searchLink fieldCode="AU" term="%22Kopczak+A%22">Kopczak A</searchLink>; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Stringer+MS%22">Stringer MS</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22van+den+Brink+H%22">van den Brink H</searchLink>; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kerkhofs+D%22">Kerkhofs D</searchLink>; Department of Neurology and School for Cardiovascular Diseases, Maastricht University Medical Center+, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Blair+GW%22">Blair GW</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22van+Dinther+M%22">van Dinther M</searchLink>; Department of Neurology and School for Cardiovascular Diseases, Maastricht University Medical Center+, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Reyes+CA%22">Reyes CA</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Garcia+DJ%22">Garcia DJ</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Onkenhout+L%22">Onkenhout L</searchLink>; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Wartolowska+KA%22">Wartolowska KA</searchLink>; Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Thrippleton+MJ%22">Thrippleton MJ</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Kampaite+A%22">Kampaite A</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Duering+M%22">Duering M</searchLink>; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany; Medical Image Analysis Center and Department of Biomedical Engineering, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Staals+J%22">Staals J</searchLink>; Department of Neurology and School for Cardiovascular Diseases, Maastricht University Medical Center+, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Lesnik-Oberstein+S%22">Lesnik-Oberstein S</searchLink>; Department of Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Muir+KW%22">Muir KW</searchLink>; School of Psychology and Neuroscience, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Middeke+M%22">Middeke M</searchLink>; Hypertoniezentrum München, Excellence Centre of the European Society of Hypertension, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Norrving+B%22">Norrving B</searchLink>; Department of Clinical Sciences Lund, Neurology, Skåne University Hospital, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Bousser+MG%22">Bousser MG</searchLink>; Hôpital Lariboisière, APHP, Université Paris-Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mansmann+U%22">Mansmann U</searchLink>; Institute for Medical Information Processing, Biometry, and Epidemiology, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Rothwell+PM%22">Rothwell PM</searchLink>; Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Doubal+FN%22">Doubal FN</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22van+Oostenbrugge+R%22">van Oostenbrugge R</searchLink>; Department of Neurology and School for Cardiovascular Diseases, Maastricht University Medical Center+, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Biessels+GJ%22">Biessels GJ</searchLink>; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Webb+AJS%22">Webb AJS</searchLink>; Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Wardlaw+JM%22">Wardlaw JM</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Dichgans+M%22">Dichgans M</searchLink>; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany; German Center for Neurodegenerative Diseases, Munich, Germany; German Centre for Cardiovascular Research, Munich, Germany. Electronic address: martin.dichgans@med.uni-muenchen.de.
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