Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells.

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Title: Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells.
Authors: Blandino G; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Fiorani M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy. Electronic address: mara.fiorani@uniurb.it., Canonico B; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., De Matteis R; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Guidarelli A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Montanari M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Buffi G; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Coppo L; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Arnér ESJ; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Department of Selenoprotein Research and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary., Cantoni O; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Source: Redox biology [Redox Biol] 2023 Nov; Vol. 67, pp. 102915. Date of Electronic Publication: 2023 Oct 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2213-2317
DOI:10.1016/j.redox.2023.102915