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Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues.

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Title: Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues.
Authors: Hassan MM; Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA., Li YD; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA., Ma MW; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Teng M; Center for Drug Discovery, Department of Pathology & Immunology, and Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX., Byun WS; Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA., Puvar K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Lumpkin R; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Sandoval B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Rutter JC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA., Jin CY; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Wang MY; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA., Xu S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Schmoker AM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Cheong H; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Groendyke BJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA., Qi J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA.; Howard Hughes Medical Institute, Boston, MA., Gray NS; Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 10. Date of Electronic Publication: 2023 Oct 10.
Publication Type: Preprint; Journal Article
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hassan+MM%22">Hassan MM</searchLink>; Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA.<br /><searchLink fieldCode="AU" term="%22Li+YD%22">Li YD</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Ma+MW%22">Ma MW</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Teng+M%22">Teng M</searchLink>; Center for Drug Discovery, Department of Pathology & Immunology, and Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Byun+WS%22">Byun WS</searchLink>; Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA.<br /><searchLink fieldCode="AU" term="%22Puvar+K%22">Puvar K</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Lumpkin+R%22">Lumpkin R</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Sandoval+B%22">Sandoval B</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Rutter+JC%22">Rutter JC</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Jin+CY%22">Jin CY</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Wang+MY%22">Wang MY</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Schmoker+AM%22">Schmoker AM</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Cheong+H%22">Cheong H</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Groendyke+BJ%22">Groendyke BJ</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Fischer+ES%22">Fischer ES</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Ebert+BL%22">Ebert BL</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA.; Howard Hughes Medical Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Gray+NS%22">Gray NS</searchLink>; Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA.
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