Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine.

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Title: Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine.
Authors: Ertveldt T; Laboratory for Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium., Meulewaeter S; Ghent research Group on Nanomedicines, Laboratory of Physical Pharmacy and General Biochemistry, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University Hospital, Ghent University, Ghent B-9000, Belgium., De Vlaeminck Y; Laboratory for Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium., Olarte O; Biostatistics and Medical Informatics Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium., Broos K; Laboratory for Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium., Van Calenbergh S; Laboratory of Medicinal Chemistry, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000, Belgium., Bourgeois S; Beta Cell Neogenesis (BENE), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium., Deprez J; Ghent research Group on Nanomedicines, Laboratory of Physical Pharmacy and General Biochemistry, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University Hospital, Ghent University, Ghent B-9000, Belgium., Heremans Y; Visual and Spatial Tissue Analysis (VSTA) Core Facility, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium., Goyvaerts C; Laboratory for Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium., Staels W; Beta Cell Neogenesis (BENE), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium.; Universitair Ziekenhuis Brussel (UZ Brussel), Department of Pediatrics, Division of Pediatric Endocrinology, Brussels, Belgium., De Smedt S; Ghent research Group on Nanomedicines, Laboratory of Physical Pharmacy and General Biochemistry, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University Hospital, Ghent University, Ghent B-9000, Belgium., Dewitte H; Ghent research Group on Nanomedicines, Laboratory of Physical Pharmacy and General Biochemistry, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University Hospital, Ghent University, Ghent B-9000, Belgium., Devoogdt N; Medical Imaging department, In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium., Keyaerts M; Medical Imaging department, In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.; Nuclear Medicine Department, UZ Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium., Verbeke R; Ghent research Group on Nanomedicines, Laboratory of Physical Pharmacy and General Biochemistry, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University Hospital, Ghent University, Ghent B-9000, Belgium., Barbé K; Biostatistics and Medical Informatics Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium., Lentacker I; Ghent research Group on Nanomedicines, Laboratory of Physical Pharmacy and General Biochemistry, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University Hospital, Ghent University, Ghent B-9000, Belgium., Breckpot K; Laboratory for Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.
Source: Theranostics [Theranostics] 2023 Oct 09; Vol. 13 (15), pp. 5483-5500. Date of Electronic Publication: 2023 Oct 09 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1838-7640
DOI:10.7150/thno.85106