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Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy.

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Title: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy.
Authors: Qu G; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Merchant JP; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Clatot J; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; The Epilepsy NeuroGenetics Initiative, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., DeFlitch LM; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Frederick DJ; Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Tang S; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Salvatore M; Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Zhang X; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Li J; Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Anderson SA; The Epilepsy NeuroGenetics Initiative, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Goldberg EM; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; The Epilepsy NeuroGenetics Initiative, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Source: Brain : a journal of neurology [Brain] 2024 Apr 04; Vol. 147 (4), pp. 1247-1263.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy.
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  Data: <searchLink fieldCode="AU" term="%22Qu+G%22">Qu G</searchLink>; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Merchant+JP%22">Merchant JP</searchLink>; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Clatot+J%22">Clatot J</searchLink>; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; The Epilepsy NeuroGenetics Initiative, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22DeFlitch+LM%22">DeFlitch LM</searchLink>; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Frederick+DJ%22">Frederick DJ</searchLink>; Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Tang+S%22">Tang S</searchLink>; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Salvatore+M%22">Salvatore M</searchLink>; Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+SA%22">Anderson SA</searchLink>; The Epilepsy NeuroGenetics Initiative, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Goldberg+EM%22">Goldberg EM</searchLink>; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; The Epilepsy NeuroGenetics Initiative, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
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              Text: 2024 Apr 04
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