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PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia.

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Title: PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia.
Authors: Alshamleh I; Center for Biomolecular Magnetic Resonance (BMRZ), Institute of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany., Kurrle N; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany., Makowka P; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany., Bhayadia R; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.; Department of Pediatrics, Goethe University Frankfurt, 60590, Frankfurt, Germany., Kumar R; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596, Frankfurt am Main, Germany., Süsser S; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany., Seibert M; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany., Ludig D; Center for Biomolecular Magnetic Resonance (BMRZ), Institute of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany., Wolf S; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany., Koschade SE; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany., Stoschek K; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany., Kreitz J; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany., Fuhrmann DC; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590, Frankfurt am Main, Germany., Toenges R; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany., Notaro M; enGene Statistics GmbH, Basel, Switzerland., Comoglio F; enGene Statistics GmbH, Basel, Switzerland., Schuringa JJ; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Berg T; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Centre for Discovery in Cancer Research and Department of Oncology, McMaster University, Hamilton, ON, Canada., Brüne B; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590, Frankfurt am Main, Germany.; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology, 60596, Frankfurt am Main, Germany., Krause DS; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596, Frankfurt am Main, Germany.; Georg-Speyer-Haus; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Klusmann JH; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.; Department of Pediatrics, Goethe University Frankfurt, 60590, Frankfurt, Germany., Oellerich T; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany., Schnütgen F; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany. schnuetgen@em.uni-frankfurt.de.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany. schnuetgen@em.uni-frankfurt.de.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany. schnuetgen@em.uni-frankfurt.de., Schwalbe H; Center for Biomolecular Magnetic Resonance (BMRZ), Institute of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany. schwalbe@nmr.uni-frankfurt.de.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany. schwalbe@nmr.uni-frankfurt.de.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany. schwalbe@nmr.uni-frankfurt.de., Serve H; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany. Hubert.Serve@kgu.de.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany. Hubert.Serve@kgu.de.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany. Hubert.Serve@kgu.de.
Source: Leukemia [Leukemia] 2023 Dec; Vol. 37 (12), pp. 2367-2382. Date of Electronic Publication: 2023 Nov 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Alshamleh+I%22">Alshamleh I</searchLink>; Center for Biomolecular Magnetic Resonance (BMRZ), Institute of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kurrle+N%22">Kurrle N</searchLink>; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Makowka+P%22">Makowka P</searchLink>; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Bhayadia+R%22">Bhayadia R</searchLink>; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.; Department of Pediatrics, Goethe University Frankfurt, 60590, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kumar+R%22">Kumar R</searchLink>; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Süsser+S%22">Süsser S</searchLink>; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Seibert+M%22">Seibert M</searchLink>; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Ludig+D%22">Ludig D</searchLink>; Center for Biomolecular Magnetic Resonance (BMRZ), Institute of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+S%22">Wolf S</searchLink>; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Koschade+SE%22">Koschade SE</searchLink>; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Stoschek+K%22">Stoschek K</searchLink>; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kreitz+J%22">Kreitz J</searchLink>; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Fuhrmann+DC%22">Fuhrmann DC</searchLink>; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Toenges+R%22">Toenges R</searchLink>; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Notaro+M%22">Notaro M</searchLink>; enGene Statistics GmbH, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Comoglio+F%22">Comoglio F</searchLink>; enGene Statistics GmbH, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schuringa+JJ%22">Schuringa JJ</searchLink>; Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Berg+T%22">Berg T</searchLink>; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Centre for Discovery in Cancer Research and Department of Oncology, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Brüne+B%22">Brüne B</searchLink>; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60590, Frankfurt am Main, Germany.; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology, 60596, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Krause+DS%22">Krause DS</searchLink>; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596, Frankfurt am Main, Germany.; Georg-Speyer-Haus; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Klusmann+JH%22">Klusmann JH</searchLink>; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.; Department of Pediatrics, Goethe University Frankfurt, 60590, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Oellerich+T%22">Oellerich T</searchLink>; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Schnütgen+F%22">Schnütgen F</searchLink>; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany. schnuetgen@em.uni-frankfurt.de.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany. schnuetgen@em.uni-frankfurt.de.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany. schnuetgen@em.uni-frankfurt.de.<br /><searchLink fieldCode="AU" term="%22Schwalbe+H%22">Schwalbe H</searchLink>; Center for Biomolecular Magnetic Resonance (BMRZ), Institute of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany. schwalbe@nmr.uni-frankfurt.de.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany. schwalbe@nmr.uni-frankfurt.de.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany. schwalbe@nmr.uni-frankfurt.de.<br /><searchLink fieldCode="AU" term="%22Serve+H%22">Serve H</searchLink>; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, Germany. Hubert.Serve@kgu.de.; Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590, Frankfurt, Germany. Hubert.Serve@kgu.de.; Frankfurt Cancer Institute, Goethe University Frankfurt, 60596, Frankfurt, Germany. Hubert.Serve@kgu.de.
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