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Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.

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Title: Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Authors: Mok S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Hong D; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Shears MJ; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Ross LS; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Ward KE; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Dhingra SK; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Kanai M; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Bridgford JL; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Tripathi AK; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Mlambo G; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Burkhard AY; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Ansbro MR; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Fairhurst KJ; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Gil-Iturbe E; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA., Park H; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Rozenberg FD; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Kim J; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA., Mancia F; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA., Fairhurst RM; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Quick M; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA., Uhlemann AC; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Sinnis P; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Source: Science advances [Sci Adv] 2023 Nov 10; Vol. 9 (45), pp. eadi2364. Date of Electronic Publication: 2023 Nov 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mok+S%22">Mok S</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yeo+T%22">Yeo T</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hong+D%22">Hong D</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; 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Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bridgford+JL%22">Bridgford JL</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tripathi+AK%22">Tripathi AK</searchLink>; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mlambo+G%22">Mlambo G</searchLink>; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Burkhard+AY%22">Burkhard AY</searchLink>; 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Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mancia+F%22">Mancia F</searchLink>; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fairhurst+RM%22">Fairhurst RM</searchLink>; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Quick+M%22">Quick M</searchLink>; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Uhlemann+AC%22">Uhlemann AC</searchLink>; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sinnis+P%22">Sinnis P</searchLink>; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fidock+DA%22">Fidock DA</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
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