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Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.

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Title: Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.
Authors: O'Donnell VB; Systems Immunity Research Institute, School of Medicine, Cardiff University, CF14 4XN, Cardiff, Wales, UK. O-donnellvb@cardiff.ac.uk., Schebb NH; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences University of Wuppertal, Gausstraße 20, 42119, Wuppertal, Germany., Milne GL; Division of Clinical Pharmacology, Vanderbilt University, 502A Robinson Research Building, Nashville, TN, 37232-6602, USA., Murphy MP; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK., Thomas CP; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3AT, UK., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt, Germany., Gelhaus SL; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Kühn H; Institute of Biochemistry, University Medicine Berlin - Charité, Berlin, Germany., Gelb MH; Department of Chemistry, University of Washington, Seattle, WA, 98195, USA., Jakobsson PJ; Rheumatology Unit, Dep. of Medicine, Solna, Karolinska Institutet & Karolinska University Hospital, Stockholm, Sweden., Blair IA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Murphy RC; Department of Pharmacology, University of Colorado Denver, Aurora, CO, 80045, USA., Freeman BA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Brash AR; Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA., FitzGerald GA; Institute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, PA, 19104, USA. garret@upenn.edu.
Source: Nature communications [Nat Commun] 2023 Nov 09; Vol. 14 (1), pp. 7172. Date of Electronic Publication: 2023 Nov 09.
Publication Type: Letter; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22O'Donnell+VB%22">O'Donnell VB</searchLink>; Systems Immunity Research Institute, School of Medicine, Cardiff University, CF14 4XN, Cardiff, Wales, UK. O-donnellvb@cardiff.ac.uk.<br /><searchLink fieldCode="AU" term="%22Schebb+NH%22">Schebb NH</searchLink>; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences University of Wuppertal, Gausstraße 20, 42119, Wuppertal, Germany.<br /><searchLink fieldCode="AU" term="%22Milne+GL%22">Milne GL</searchLink>; Division of Clinical Pharmacology, Vanderbilt University, 502A Robinson Research Building, Nashville, TN, 37232-6602, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+MP%22">Murphy MP</searchLink>; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Thomas+CP%22">Thomas CP</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Steinhilber+D%22">Steinhilber D</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Gelhaus+SL%22">Gelhaus SL</searchLink>; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.<br /><searchLink fieldCode="AU" term="%22Kühn+H%22">Kühn H</searchLink>; Institute of Biochemistry, University Medicine Berlin - Charité, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gelb+MH%22">Gelb MH</searchLink>; Department of Chemistry, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Jakobsson+PJ%22">Jakobsson PJ</searchLink>; Rheumatology Unit, Dep. of Medicine, Solna, Karolinska Institutet & Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Blair+IA%22">Blair IA</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+RC%22">Murphy RC</searchLink>; Department of Pharmacology, University of Colorado Denver, Aurora, CO, 80045, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+BA%22">Freeman BA</searchLink>; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.<br /><searchLink fieldCode="AU" term="%22Brash+AR%22">Brash AR</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22FitzGerald+GA%22">FitzGerald GA</searchLink>; Institute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, PA, 19104, USA. garret@upenn.edu.
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