Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes.

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Title: Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes.
Authors: Ren R; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK.; Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK., Cai S; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK. shenglin.cai15@imperial.ac.uk.; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. shenglin.cai15@imperial.ac.uk., Fang X; The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Aptamer Selection Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 310022, Hangzhou, Zhejiang, China., Wang X; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK., Zhang Z; The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Aptamer Selection Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 310022, Hangzhou, Zhejiang, China., Damiani M; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK., Hudlerova C; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK., Rosa A; The Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, UK.; Wolfson Education Centre, Faculty of Medicine, Imperial College London, London, UK., Hope J; The Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, UK., Cook NJ; The Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, UK., Gorelkin P; National University of Science and Technology 'MISIS', Leninskiy Prospect 4, 119991, Moscow, Russian Federation., Erofeev A; National University of Science and Technology 'MISIS', Leninskiy Prospect 4, 119991, Moscow, Russian Federation., Novak P; ICAPPIC Limited, The Fisheries, Mentmore Terrace, London, E8 3PN, UK., Badhan A; Molecular Diagnostic Unit, Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK., Crone M; Section of Structural and Synthetic Biology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK., Freemont P; Section of Structural and Synthetic Biology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK., Taylor GP; Molecular Diagnostic Unit, Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK., Tang L; State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, 310027, Hangzhou, China., Edwards C; Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.; ICAPPIC Limited, The Fisheries, Mentmore Terrace, London, E8 3PN, UK., Shevchuk A; Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK., Cherepanov P; The Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, UK.; Molecular Diagnostic Unit, Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK., Luo Z; The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Aptamer Selection Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 310022, Hangzhou, Zhejiang, China., Tan W; The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Aptamer Selection Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 310022, Hangzhou, Zhejiang, China. tan@hnu.edu.cn., Korchev Y; Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.; Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan., Ivanov AP; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK. alex.ivanov@imperial.ac.uk., Edel JB; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK. joshua.edel@imperial.ac.uk.
Source: Nature communications [Nat Commun] 2023 Nov 14; Vol. 14 (1), pp. 7362. Date of Electronic Publication: 2023 Nov 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes.
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  Data: <searchLink fieldCode="AU" term="%22Ren+R%22">Ren R</searchLink>; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK.; Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Cai+S%22">Cai S</searchLink>; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK. shenglin.cai15@imperial.ac.uk.; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. shenglin.cai15@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Fang+X%22">Fang X</searchLink>; The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Aptamer Selection Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 310022, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Aptamer Selection Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 310022, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Damiani+M%22">Damiani M</searchLink>; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK.<br /><searchLink fieldCode="AU" term="%22Hudlerova+C%22">Hudlerova C</searchLink>; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK.<br /><searchLink fieldCode="AU" term="%22Rosa+A%22">Rosa A</searchLink>; The Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, UK.; 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Molecular Diagnostic Unit, Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Crone+M%22">Crone M</searchLink>; Section of Structural and Synthetic Biology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Freemont+P%22">Freemont P</searchLink>; Section of Structural and Synthetic Biology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Taylor+GP%22">Taylor GP</searchLink>; Molecular Diagnostic Unit, Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tang+L%22">Tang L</searchLink>; State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, 310027, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Edwards+C%22">Edwards C</searchLink>; 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The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Aptamer Selection Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 310022, Hangzhou, Zhejiang, China. tan@hnu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Korchev+Y%22">Korchev Y</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.; Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.<br /><searchLink fieldCode="AU" term="%22Ivanov+AP%22">Ivanov AP</searchLink>; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK. alex.ivanov@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Edel+JB%22">Edel JB</searchLink>; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, 82 Wood Lane, London, W12 0BZ, UK. joshua.edel@imperial.ac.uk.
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