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Salvage therapy expands highly cytotoxic and metabolically fit resilient CD8+ T cells via ME1 up-regulation.

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Title: Salvage therapy expands highly cytotoxic and metabolically fit resilient CD8+ T cells via ME1 up-regulation.
Authors: Gicobi JK; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Mao Z; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., DeFranco G; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Hirdler JB; Department of Urology, Mayo Clinic, Rochester, MN, USA., Li Y; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA., Vianzon VV; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Dellacecca ER; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Hsu MA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Barham W; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Yan Y; Division of Medical Oncology, Mayo Clinic, Jacksonville, FL, USA., Mansfield AS; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Lin Y; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Wu X; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Hitosugi T; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Owen D; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Grams MP; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Orme JJ; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Lucien F; Department of Urology, Mayo Clinic, Rochester, MN, USA., Zeng H; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Rheumatology, Mayo Clinic, Rochester, MN, USA., Park SS; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Dong H; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Urology, Mayo Clinic, Rochester, MN, USA.
Source: Science advances [Sci Adv] 2023 Nov 17; Vol. 9 (46), pp. eadi2414. Date of Electronic Publication: 2023 Nov 15.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Salvage therapy expands highly cytotoxic and metabolically fit resilient CD8<superscript>+</superscript> T cells via ME1 up-regulation.
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  Data: <searchLink fieldCode="AU" term="%22Gicobi+JK%22">Gicobi JK</searchLink>; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Mao+Z%22">Mao Z</searchLink>; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22DeFranco+G%22">DeFranco G</searchLink>; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hirdler+JB%22">Hirdler JB</searchLink>; Department of Urology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Vianzon+VV%22">Vianzon VV</searchLink>; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Dellacecca+ER%22">Dellacecca ER</searchLink>; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+MA%22">Hsu MA</searchLink>; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Barham+W%22">Barham W</searchLink>; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Yan+Y%22">Yan Y</searchLink>; Division of Medical Oncology, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Mansfield+AS%22">Mansfield AS</searchLink>; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hitosugi+T%22">Hitosugi T</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Owen+D%22">Owen D</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Grams+MP%22">Grams MP</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Orme+JJ%22">Orme JJ</searchLink>; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Lucien+F%22">Lucien F</searchLink>; Department of Urology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+H%22">Zeng H</searchLink>; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Rheumatology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Park+SS%22">Park SS</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Dong+H%22">Dong H</searchLink>; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.; Department of Urology, Mayo Clinic, Rochester, MN, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2023 Nov 17; Vol. 9 (46), pp. eadi2414. <i>Date of Electronic Publication: </i>2023 Nov 15.
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