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Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.

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Title: Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.
Authors: Nelson AN; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Shen X; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Vekatayogi S; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Zhang S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Dennis M; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Sewall LM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Milligan E; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA., Davis D; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA., Cross KA; Gillings School of Public Health and Center for AIDS Research, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA., Chen Y; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., van Schooten J; Department of Medical Microbiology, Academic Medical Center; Amsterdam, Netherlands., Eudailey J; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Isaac J; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Memon S; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Weinbaum C; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA., Stanfield-Oakley S; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Byrd A; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Chutkan S; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Berendam S; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Cronin K; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Yasmeen A; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA., Alam SM; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., LaBranche CC; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Rogers K; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Shirreff L; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Cupo A; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA., Derking R; Department of Medical Microbiology, Academic Medical Center; Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Villinger F; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Klasse PJ; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA., Ferrari G; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Williams WB; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Hudgens MG; Gillings School of Public Health and Center for AIDS Research, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Montefiori DC; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Van Rompay KKA; California National Primate Research Center, University of California; Davis, CA, USA., Wiehe K; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA., Moore JP; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA., Sanders RW; Department of Medical Microbiology, Academic Medical Center; Amsterdam, Netherlands.; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., De Paris K; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA., Permar SR; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 11. Date of Electronic Publication: 2023 Nov 11.
Publication Type: Preprint; Journal Article
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Availability: 0
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.
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  Data: <searchLink fieldCode="AU" term="%22Nelson+AN%22">Nelson AN</searchLink>; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Vekatayogi+S%22">Vekatayogi S</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ozorowski+G%22">Ozorowski G</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dennis+M%22">Dennis M</searchLink>; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sewall+LM%22">Sewall LM</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Milligan+E%22">Milligan E</searchLink>; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Davis+D%22">Davis D</searchLink>; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Cross+KA%22">Cross KA</searchLink>; Gillings School of Public Health and Center for AIDS Research, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22van+Schooten+J%22">van Schooten J</searchLink>; Department of Medical Microbiology, Academic Medical Center; Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Eudailey+J%22">Eudailey J</searchLink>; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Isaac+J%22">Isaac J</searchLink>; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Memon+S%22">Memon S</searchLink>; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Weinbaum+C%22">Weinbaum C</searchLink>; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Stanfield-Oakley+S%22">Stanfield-Oakley S</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Byrd+A%22">Byrd A</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chutkan+S%22">Chutkan S</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Berendam+S%22">Berendam S</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Cronin+K%22">Cronin K</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Yasmeen+A%22">Yasmeen A</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Alam+SM%22">Alam SM</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22LaBranche+CC%22">LaBranche CC</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Rogers+K%22">Rogers K</searchLink>; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA.<br /><searchLink fieldCode="AU" term="%22Shirreff+L%22">Shirreff L</searchLink>; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA.<br /><searchLink fieldCode="AU" term="%22Cupo+A%22">Cupo A</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Derking+R%22">Derking R</searchLink>; Department of Medical Microbiology, Academic Medical Center; Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Villinger+F%22">Villinger F</searchLink>; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA.<br /><searchLink fieldCode="AU" term="%22Klasse+PJ%22">Klasse PJ</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ferrari+G%22">Ferrari G</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Williams+WB%22">Williams WB</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hudgens+MG%22">Hudgens MG</searchLink>; Gillings School of Public Health and Center for AIDS Research, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Montefiori+DC%22">Montefiori DC</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Van+Rompay+KKA%22">Van Rompay KKA</searchLink>; California National Primate Research Center, University of California; Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wiehe+K%22">Wiehe K</searchLink>; Human Vaccine Institute, Duke University Medical Center; Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Moore+JP%22">Moore JP</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sanders+RW%22">Sanders RW</searchLink>; Department of Medical Microbiology, Academic Medical Center; Amsterdam, Netherlands.; Department of Microbiology and Immunology, Weill Cornell Medicine; New York, NY, USA.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22De+Paris+K%22">De Paris K</searchLink>; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Permar+SR%22">Permar SR</searchLink>; Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.
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