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Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.

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Title: Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.
Authors: Bedard GT; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA., Gilaj N; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Chemistry, Lehman College, Bronx, New York, USA., Peregrina K; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA., Brew I; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA., Tosti E; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA., Shaffer K; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand., Tyler PC; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand., Edelmann W; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA., Augenlicht LH; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA., Schramm VL; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: vern.schramm@einsteinmed.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2024 Jan; Vol. 300 (1), pp. 105492. Date of Electronic Publication: 2023 Nov 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Bedard+GT%22">Bedard GT</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Gilaj+N%22">Gilaj N</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Chemistry, Lehman College, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Peregrina+K%22">Peregrina K</searchLink>; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Brew+I%22">Brew I</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Tosti+E%22">Tosti E</searchLink>; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Shaffer+K%22">Shaffer K</searchLink>; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.<br /><searchLink fieldCode="AU" term="%22Tyler+PC%22">Tyler PC</searchLink>; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.<br /><searchLink fieldCode="AU" term="%22Edelmann+W%22">Edelmann W</searchLink>; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Augenlicht+LH%22">Augenlicht LH</searchLink>; Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Schramm+VL%22">Schramm VL</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: vern.schramm@einsteinmed.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2024 Jan; Vol. 300 (1), pp. 105492. <i>Date of Electronic Publication: </i>2023 Nov 23.
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  Data: Journal Article; Research Support, N.I.H., Extramural
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2023.105492
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      – TitleFull: Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.
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              Text: 2024 Jan
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