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Safety, pharmacokinetics, and target engagement of a brain penetrant RIPK1 inhibitor, SAR443820 (DNL788), in healthy adult participants.

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Title: Safety, pharmacokinetics, and target engagement of a brain penetrant RIPK1 inhibitor, SAR443820 (DNL788), in healthy adult participants.
Authors: Hincelin-Mery A; Sanofi, Chilly-Mazarin, France., Nicolas X; Sanofi, Montpellier, France., Cantalloube C; Sanofi, Chilly-Mazarin, France., Pomponio R; Sanofi, Cambridge, Massachusetts, USA., Lewanczyk P; Ividata Life Sciences, Levallois-Perret, France., Benamor M; Sanofi, Chilly-Mazarin, France., Ofengeim D; Sanofi, Cambridge, Massachusetts, USA., Krupka E; Sanofi, Montpellier, France., Hsiao-Nakamoto J; Denali Therapeutics Inc., South San Francisco, California, USA., Eastenson A; Nucleus Network Pty Ltd., St. Paul, Minnesota, USA., Atassi N; Sanofi, Cambridge, Massachusetts, USA.
Source: Clinical and translational science [Clin Transl Sci] 2024 Jan; Vol. 17 (1), pp. e13690. Date of Electronic Publication: 2023 Dec 11.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety, pharmacokinetics, and target engagement of a brain penetrant RIPK1 inhibitor, SAR443820 (DNL788), in healthy adult participants.
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  Data: <searchLink fieldCode="AU" term="%22Hincelin-Mery+A%22">Hincelin-Mery A</searchLink>; Sanofi, Chilly-Mazarin, France.<br /><searchLink fieldCode="AU" term="%22Nicolas+X%22">Nicolas X</searchLink>; Sanofi, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Cantalloube+C%22">Cantalloube C</searchLink>; Sanofi, Chilly-Mazarin, France.<br /><searchLink fieldCode="AU" term="%22Pomponio+R%22">Pomponio R</searchLink>; Sanofi, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lewanczyk+P%22">Lewanczyk P</searchLink>; Ividata Life Sciences, Levallois-Perret, France.<br /><searchLink fieldCode="AU" term="%22Benamor+M%22">Benamor M</searchLink>; Sanofi, Chilly-Mazarin, France.<br /><searchLink fieldCode="AU" term="%22Ofengeim+D%22">Ofengeim D</searchLink>; Sanofi, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Krupka+E%22">Krupka E</searchLink>; Sanofi, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Hsiao-Nakamoto+J%22">Hsiao-Nakamoto J</searchLink>; Denali Therapeutics Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Eastenson+A%22">Eastenson A</searchLink>; Nucleus Network Pty Ltd., St. Paul, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Atassi+N%22">Atassi N</searchLink>; Sanofi, Cambridge, Massachusetts, USA.
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              Text: 2024 Jan
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