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Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis.

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Title: Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis.
Authors: Leone MA; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Gelati M; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Profico DC; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Gobbi C; Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), 6900 Lugano, Switzerland., Pravatà E; Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), 6900 Lugano, Switzerland; Department of Neuroradiology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland., Copetti M; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Conti C; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17th A - L18-9118, Aurora, CO, USA., Abate L; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Amoruso L; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Apollo F; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Balzano RF; Department of Neuroradiology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland., Bicchi I; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Carella M; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Ciampini A; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Colosimo C; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Crociani P; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., D'Aloisio G; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Di Viesti P; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Ferrari D; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy., Fogli D; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Fontana A; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Frondizi D; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Grespi V; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Kuhle J; Department of Neurology, University Hospital Basel, and University of Basel, Basel, Switzerland., Laborante A; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Lombardi I; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy., Muzi G; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Paci F; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Placentino G; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Popolizio T; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Ricciolini C; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Sabatini S; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Silveri G; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Spera C; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Stephenson D; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17th A - L18-9118, Aurora, CO, USA., Stipa G; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Tinella E; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy., Zarrelli M; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy., Zecca C; Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), 6900 Lugano, Switzerland., Ventura Y; Abu Dhabi Stem Cell Centre, Abu Dhabi, United Arab Emirates., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17th A - L18-9118, Aurora, CO, USA., Peruzzotti-Jametti L; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, CB2 0QQ Cambridge, UK; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Pluchino S; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, CB2 0QQ Cambridge, UK. Electronic address: spp24@cam.ac.uk., Vescovi AL; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. Electronic address: angelo.vescovi@unimib.it.
Source: Cell stem cell [Cell Stem Cell] 2023 Dec 07; Vol. 30 (12), pp. 1597-1609.e8. Date of Electronic Publication: 2023 Nov 27.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Leone+MA%22">Leone MA</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Gelati+M%22">Gelati M</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Profico+DC%22">Profico DC</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Gobbi+C%22">Gobbi C</searchLink>; Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), 6900 Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pravatà+E%22">Pravatà E</searchLink>; Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), 6900 Lugano, Switzerland; Department of Neuroradiology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Copetti+M%22">Copetti M</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Conti+C%22">Conti C</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17th A - L18-9118, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Abate+L%22">Abate L</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Amoruso+L%22">Amoruso L</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Apollo+F%22">Apollo F</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Balzano+RF%22">Balzano RF</searchLink>; Department of Neuroradiology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bicchi+I%22">Bicchi I</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Carella+M%22">Carella M</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Ciampini+A%22">Ciampini A</searchLink>; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Colosimo+C%22">Colosimo C</searchLink>; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Crociani+P%22">Crociani P</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22D'Aloisio+G%22">D'Aloisio G</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Viesti+P%22">Di Viesti P</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrari+D%22">Ferrari D</searchLink>; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fogli+D%22">Fogli D</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Fontana+A%22">Fontana A</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Frondizi+D%22">Frondizi D</searchLink>; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Grespi+V%22">Grespi V</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Kuhle+J%22">Kuhle J</searchLink>; Department of Neurology, University Hospital Basel, and University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Laborante+A%22">Laborante A</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Lombardi+I%22">Lombardi I</searchLink>; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Muzi+G%22">Muzi G</searchLink>; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Paci+F%22">Paci F</searchLink>; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Placentino+G%22">Placentino G</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Popolizio+T%22">Popolizio T</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Ricciolini+C%22">Ricciolini C</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Sabatini+S%22">Sabatini S</searchLink>; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Silveri+G%22">Silveri G</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Spera+C%22">Spera C</searchLink>; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Stephenson+D%22">Stephenson D</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17th A - L18-9118, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Stipa+G%22">Stipa G</searchLink>; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Tinella+E%22">Tinella E</searchLink>; AOSP Santa Maria, via Tristano di Joannuccio 1, 05100 Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Zarrelli+M%22">Zarrelli M</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Zecca+C%22">Zecca C</searchLink>; Multiple Sclerosis Centre (MSC), Department of Neurology, Neurocentre of Southern Switzerland, EOC, 6900 Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), 6900 Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ventura+Y%22">Ventura Y</searchLink>; Abu Dhabi Stem Cell Centre, Abu Dhabi, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22D'Alessandro+A%22">D'Alessandro A</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17th A - L18-9118, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Peruzzotti-Jametti+L%22">Peruzzotti-Jametti L</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, CB2 0QQ Cambridge, UK; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pluchino+S%22">Pluchino S</searchLink>; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, CB2 0QQ Cambridge, UK. Electronic address: spp24@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Vescovi+AL%22">Vescovi AL</searchLink>; IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. Electronic address: angelo.vescovi@unimib.it.
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  Data: <searchLink fieldCode="JN" term="%22101311472%22">Cell stem cell</searchLink> [Cell Stem Cell] 2023 Dec 07; Vol. 30 (12), pp. 1597-1609.e8. <i>Date of Electronic Publication: </i>2023 Nov 27.
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              Value: 30
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: Cell stem cell
              Type: main
ResultId 1