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GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury.

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Title: GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury.
Authors: Brightwell CR; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Latham CM; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Keeble AR; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Thomas NT; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Owen AM; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Reeves KA; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Long DE; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA., Patrick M; Department of Biomedical Engineering, College of Engineering, University of Kentucky, Lexington, KY, USA., Gonzalez-Velez S; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA., Abed V; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Annamalai RT; Department of Biomedical Engineering, College of Engineering, University of Kentucky, Lexington, KY, USA., Jacobs C; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Conley CE; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Hawk GS; Department of Statistics, College of Arts and Sciences, University of Kentucky, Lexington, KY, USA., Stone AV; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Fry JL; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Thompson KL; Department of Statistics, College of Arts and Sciences, University of Kentucky, Lexington, KY, USA., Johnson DL; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Noehren B; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA.; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Fry CS; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA.
Source: Science advances [Sci Adv] 2023 Dec; Vol. 9 (48), pp. eadi9134. Date of Electronic Publication: 2023 Nov 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Brightwell+CR%22">Brightwell CR</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Latham+CM%22">Latham CM</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Keeble+AR%22">Keeble AR</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+NT%22">Thomas NT</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Owen+AM%22">Owen AM</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Reeves+KA%22">Reeves KA</searchLink>; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Long+DE%22">Long DE</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Patrick+M%22">Patrick M</searchLink>; Department of Biomedical Engineering, College of Engineering, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Velez+S%22">Gonzalez-Velez S</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Abed+V%22">Abed V</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Annamalai+RT%22">Annamalai RT</searchLink>; Department of Biomedical Engineering, College of Engineering, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Jacobs+C%22">Jacobs C</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Conley+CE%22">Conley CE</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Hawk+GS%22">Hawk GS</searchLink>; Department of Statistics, College of Arts and Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Stone+AV%22">Stone AV</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Fry+JL%22">Fry JL</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+KL%22">Thompson KL</searchLink>; Department of Statistics, College of Arts and Sciences, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+DL%22">Johnson DL</searchLink>; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Noehren+B%22">Noehren B</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA.; Department of Orthopaedic Surgery and Sports Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Fry+CS%22">Fry CS</searchLink>; Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, KY, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2023 Dec; Vol. 9 (48), pp. eadi9134. <i>Date of Electronic Publication: </i>2023 Nov 29.
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