A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses.

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Title: A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses.
Authors: Smith KER; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States., Peng KW; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States., Pulido JS; Department of Ophthalmology, Wills Eye Hospital, Philadelphia, PA, United States., Weisbrod AJ; Department of Radiology, Mayo Clinic, Rochester, MN, United States., Strand CA; Department of Biostatistics and Informatics, Mayo Clinic, Rochester, MN, United States., Allred JB; Department of Biostatistics and Informatics, Mayo Clinic, Rochester, MN, United States., Newsom AN; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States., Zhang L; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States., Packiriswamy N; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States., Kottke T; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States., Tonne JM; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States., Moore M; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States., Montane HN; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States., Kottschade LA; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States., McWilliams RR; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States., Dudek AZ; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States., Yan Y; Department of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, United States., Dimou A; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States., Markovic SN; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States., Federspiel MJ; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States., Vile RG; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States., Dronca RS; Department of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, United States., Block MS; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States.
Source: Frontiers in immunology [Front Immunol] 2023 Oct 31; Vol. 14, pp. 1279387. Date of Electronic Publication: 2023 Oct 31 (Print Publication: 2023).
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses.
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  Data: <searchLink fieldCode="AU" term="%22Smith+KER%22">Smith KER</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Peng+KW%22">Peng KW</searchLink>; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Pulido+JS%22">Pulido JS</searchLink>; Department of Ophthalmology, Wills Eye Hospital, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Weisbrod+AJ%22">Weisbrod AJ</searchLink>; Department of Radiology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Strand+CA%22">Strand CA</searchLink>; Department of Biostatistics and Informatics, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Allred+JB%22">Allred JB</searchLink>; Department of Biostatistics and Informatics, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Newsom+AN%22">Newsom AN</searchLink>; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Packiriswamy+N%22">Packiriswamy N</searchLink>; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Kottke+T%22">Kottke T</searchLink>; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Tonne+JM%22">Tonne JM</searchLink>; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Moore+M%22">Moore M</searchLink>; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Montane+HN%22">Montane HN</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Kottschade+LA%22">Kottschade LA</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22McWilliams+RR%22">McWilliams RR</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Dudek+AZ%22">Dudek AZ</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Yan+Y%22">Yan Y</searchLink>; Department of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Dimou+A%22">Dimou A</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Markovic+SN%22">Markovic SN</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Federspiel+MJ%22">Federspiel MJ</searchLink>; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Vile+RG%22">Vile RG</searchLink>; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Dronca+RS%22">Dronca RS</searchLink>; Department of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, United States.<br /><searchLink fieldCode="AU" term="%22Block+MS%22">Block MS</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, MN, United States.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2023 Oct 31; Vol. 14, pp. 1279387. <i>Date of Electronic Publication: </i>2023 Oct 31 (<i>Print Publication: </i>2023).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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