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SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19.

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Title: SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19.
Authors: Sahanic S; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Hilbe R; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Dünser C; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Tymoszuk P; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Löffler-Ragg J; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Rieder D; Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria., Trajanoski Z; Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria., Krogsdam A; Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria., Demetz E; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Yurchenko M; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway.; The Central Norway Regional Health Authority, St. Olavs Hospital HF, Trondheim, Norway., Fischer C; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Schirmer M; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Theurl M; Department of Internal Medicine III, Medical University of Innsbruck, Innsbruck, Austria., Lener D; Department of Internal Medicine III, Medical University of Innsbruck, Innsbruck, Austria., Hirsch J; Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria., Holfeld J; Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria., Gollmann-Tepeköylü C; Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria., Zinner CP; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Tzankov A; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Zhang SY; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, New York, NY, 10065, USA., Posch W; Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Austria., Wilflingseder D; Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Austria., Weiss G; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria., Tancevski I; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Source: Heliyon [Heliyon] 2023 Nov 17; Vol. 9 (11), pp. e21893. Date of Electronic Publication: 2023 Nov 17 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
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  Data: SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Sahanic+S%22">Sahanic S</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Hilbe+R%22">Hilbe R</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Dünser+C%22">Dünser C</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Tymoszuk+P%22">Tymoszuk P</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Löffler-Ragg+J%22">Löffler-Ragg J</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Rieder+D%22">Rieder D</searchLink>; Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Trajanoski+Z%22">Trajanoski Z</searchLink>; Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Krogsdam+A%22">Krogsdam A</searchLink>; Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Demetz+E%22">Demetz E</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Yurchenko+M%22">Yurchenko M</searchLink>; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway.; The Central Norway Regional Health Authority, St. Olavs Hospital HF, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Fischer+C%22">Fischer C</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Schirmer+M%22">Schirmer M</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Theurl+M%22">Theurl M</searchLink>; Department of Internal Medicine III, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Lener+D%22">Lener D</searchLink>; Department of Internal Medicine III, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Hirsch+J%22">Hirsch J</searchLink>; Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Holfeld+J%22">Holfeld J</searchLink>; Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Gollmann-Tepeköylü+C%22">Gollmann-Tepeköylü C</searchLink>; Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Zinner+CP%22">Zinner CP</searchLink>; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tzankov+A%22">Tzankov A</searchLink>; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zhang+SY%22">Zhang SY</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Casanova+JL%22">Casanova JL</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Posch+W%22">Posch W</searchLink>; Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Wilflingseder+D%22">Wilflingseder D</searchLink>; Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Weiss+G%22">Weiss G</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Tancevski+I%22">Tancevski I</searchLink>; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
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