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IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson's disease models.

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Title: IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson's disease models.
Authors: Arcos J; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile., Grunenwald F; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile., Sepulveda D; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile., Jerez C; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile., Urbina V; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile., Huerta T; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile., Troncoso-Escudero P; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Molecular Diagnostic and Biomarkers Laboratory, Department of Pathology, Faculty of Medicine Clínica Alemana, Universidad del Desarrollo, Santiago, Chile., Tirado D; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Escuela de Tecnología Médica, Universidad Mayor, Santiago, Chile., Perez A; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Escuela de Tecnología Médica, Universidad Mayor, Santiago, Chile., Diaz-Espinoza R; Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile., Nova E; Departamento de Química, Facultad de Ciencias Naturales, Matemáticas y Medio Ambiente, Universidad Tecnológica Metropolitana, Santiago, Chile., Kubitscheck U; Clausius Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany., Rodriguez-Gatica JE; Clausius Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany., Hetz C; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile., Toledo J; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile., Ahumada P; Center for Integrative Biology, Universidad Mayor, Santiago, Chile., Rojas-Rivera D; Escuela de Tecnología Médica, Universidad Mayor, Santiago, Chile.; Escuela de Biotecnología, Universidad Mayor, Santiago, Chile.; Center for Biomedicine, Universidad Mayor, Santiago, Chile., Martín-Montañez E; Department of Pharmacology, Faculty of Medicine, Biomedical Research Institute of Malaga, University of Malaga, Malaga, Spain., Garcia-Fernandez M; Department of Human Physiology, Faculty of Medicine, Biomedical Research Institute of Malaga, University of Malaga, Malaga, Spain., Vidal RL; Center for Integrative Biology, Universidad Mayor, Santiago, Chile. rene.vidal@umayor.cl.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile. rene.vidal@umayor.cl.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. rene.vidal@umayor.cl.; Escuela de Tecnología Médica, Universidad Mayor, Santiago, Chile. rene.vidal@umayor.cl.; Escuela de Biotecnología, Universidad Mayor, Santiago, Chile. rene.vidal@umayor.cl.
Source: Cell death discovery [Cell Death Discov] 2023 Dec 02; Vol. 9 (1), pp. 438. Date of Electronic Publication: 2023 Dec 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
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  Data: IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson's disease models.
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  Data: <searchLink fieldCode="AU" term="%22Arcos+J%22">Arcos J</searchLink>; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Grunenwald+F%22">Grunenwald F</searchLink>; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Sepulveda+D%22">Sepulveda D</searchLink>; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Jerez+C%22">Jerez C</searchLink>; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Urbina+V%22">Urbina V</searchLink>; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Huerta+T%22">Huerta T</searchLink>; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Troncoso-Escudero+P%22">Troncoso-Escudero P</searchLink>; Center for Integrative Biology, Universidad Mayor, Santiago, Chile.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; 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Escuela de Tecnología Médica, Universidad Mayor, Santiago, Chile.; Escuela de Biotecnología, Universidad Mayor, Santiago, Chile.; Center for Biomedicine, Universidad Mayor, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Martín-Montañez+E%22">Martín-Montañez E</searchLink>; Department of Pharmacology, Faculty of Medicine, Biomedical Research Institute of Malaga, University of Malaga, Malaga, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia-Fernandez+M%22">Garcia-Fernandez M</searchLink>; Department of Human Physiology, Faculty of Medicine, Biomedical Research Institute of Malaga, University of Malaga, Malaga, Spain.<br /><searchLink fieldCode="AU" term="%22Vidal+RL%22">Vidal RL</searchLink>; Center for Integrative Biology, Universidad Mayor, Santiago, Chile. rene.vidal@umayor.cl.; Biomedical Neuroscience Institute, University of Chile, Santiago, Chile. rene.vidal@umayor.cl.; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. rene.vidal@umayor.cl.; Escuela de Tecnología Médica, Universidad Mayor, Santiago, Chile. rene.vidal@umayor.cl.; Escuela de Biotecnología, Universidad Mayor, Santiago, Chile. rene.vidal@umayor.cl.
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