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Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.

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Title: Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.
Authors: Dijkstra DJ; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., van de Bovenkamp FS; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Lava Therapeutics, Utrecht 3584 CM, The Netherlands., Abendstein L; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Zuijderduijn R; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Pool J; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Kramer CSM; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Slot LM; Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Drijfhout JW; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., de Vor L; Department of Medical Microbiology, University Medical Center, Utrecht 3584 CX, The Netherlands., Gelderman KA; Sanquin Diagnostic Services, Amsterdam 1066 CX, The Netherlands., Rooijakkers SHM; Department of Medical Microbiology, University Medical Center, Utrecht 3584 CX, The Netherlands., Zaldumbide A; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Vidarsson G; Department of Experimental Immunohematology, Sanquin Research, Amsterdam 1066 CX, The Netherlands., Sharp TH; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Parren PWHI; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Gyes BV, Naarden 1411 DC, The Netherlands., Trouw LA; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Dec 12; Vol. 120 (50), pp. e2310666120. Date of Electronic Publication: 2023 Dec 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.
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  Data: <searchLink fieldCode="AU" term="%22Dijkstra+DJ%22">Dijkstra DJ</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Bovenkamp+FS%22">van de Bovenkamp FS</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Lava Therapeutics, Utrecht 3584 CM, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Abendstein+L%22">Abendstein L</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Zuijderduijn+R%22">Zuijderduijn R</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pool+J%22">Pool J</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kramer+CSM%22">Kramer CSM</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Slot+LM%22">Slot LM</searchLink>; Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Drijfhout+JW%22">Drijfhout JW</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Vor+L%22">de Vor L</searchLink>; Department of Medical Microbiology, University Medical Center, Utrecht 3584 CX, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gelderman+KA%22">Gelderman KA</searchLink>; Sanquin Diagnostic Services, Amsterdam 1066 CX, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rooijakkers+SHM%22">Rooijakkers SHM</searchLink>; Department of Medical Microbiology, University Medical Center, Utrecht 3584 CX, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Zaldumbide+A%22">Zaldumbide A</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vidarsson+G%22">Vidarsson G</searchLink>; Department of Experimental Immunohematology, Sanquin Research, Amsterdam 1066 CX, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sharp+TH%22">Sharp TH</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Parren+PWHI%22">Parren PWHI</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Gyes BV, Naarden 1411 DC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Trouw+LA%22">Trouw LA</searchLink>; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2023 Dec 12; Vol. 120 (50), pp. e2310666120. <i>Date of Electronic Publication: </i>2023 Dec 04.
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