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Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.

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Bibliographic Details
Title: Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.
Authors: Dijkstra DJ; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., van de Bovenkamp FS; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Lava Therapeutics, Utrecht 3584 CM, The Netherlands., Abendstein L; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Zuijderduijn R; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Pool J; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Kramer CSM; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Slot LM; Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Drijfhout JW; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., de Vor L; Department of Medical Microbiology, University Medical Center, Utrecht 3584 CX, The Netherlands., Gelderman KA; Sanquin Diagnostic Services, Amsterdam 1066 CX, The Netherlands., Rooijakkers SHM; Department of Medical Microbiology, University Medical Center, Utrecht 3584 CX, The Netherlands., Zaldumbide A; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Vidarsson G; Department of Experimental Immunohematology, Sanquin Research, Amsterdam 1066 CX, The Netherlands., Sharp TH; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Parren PWHI; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Gyes BV, Naarden 1411 DC, The Netherlands., Trouw LA; Department of Immunology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Dec 12; Vol. 120 (50), pp. e2310666120. Date of Electronic Publication: 2023 Dec 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2310666120