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Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies.

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Title: Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies.
Authors: Hong JH; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore., Yong CH; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Department of Computer Science, National University of Singapore, Singapore., Heng HL; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore., Chan JY; Division of Medical Oncology, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore., Lau MC; Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Singapore.; Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), Singapore., Chen J; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Lee JY; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore., Lim AH; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore., Li Z; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore., Guan P; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore., Chu PL; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore., Boot A; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore.; Centre for Computational Biology, Duke-NUS Medical School, Singapore., Ng SR; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore., Yao X; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore., Wee FYT; Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore., Lim JCT; Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore., Liu W; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore., Wang P; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Xiao R; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Zeng X; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Sun Y; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Koh J; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore., Kwek XY; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore., Ng CCY; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore., Klanrit P; Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand.; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Zhang Y; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong., Lai J; Department of Pancreaticobiliary Surgery, Sun Yat-sen University, Guangzhou, China., Tai DWM; Division of Medical Oncology, National Cancer Centre Singapore, Singapore.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore., Pairojkul C; Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Dima S; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucuresti, Romania., Popescu I; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucuresti, Romania., Hsieh SY; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan., Yu MC; Department of General Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan., Yeong J; Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore.; Department of Anatomical Pathology, Singapore General Hospital, Singapore.; Pathology Academic Clinical Program, Duke-NUS Medical School, Singapore., Kongpetch S; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.; Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Jusakul A; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.; Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand., Loilome W; Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand.; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand., Tan P; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Tan J; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; State Key Laboratory of Oncology, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Teh BT; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore teh.bin.tean@singhealth.com.sg.; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore.; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore.
Source: Gut [Gut] 2024 May 10; Vol. 73 (6), pp. 966-984. Date of Electronic Publication: 2024 May 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies.
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  Data: <searchLink fieldCode="AU" term="%22Hong+JH%22">Hong JH</searchLink>; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Yong+CH%22">Yong CH</searchLink>; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Department of Computer Science, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Heng+HL%22">Heng HL</searchLink>; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+JY%22">Chan JY</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Lau+MC%22">Lau MC</searchLink>; Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Singapore.; Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+AH%22">Lim AH</searchLink>; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Guan+P%22">Guan P</searchLink>; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore.<br /><searchLink fieldCode="AU" term="%22Chu+PL%22">Chu PL</searchLink>; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Boot+A%22">Boot A</searchLink>; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore.; Centre for Computational Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+SR%22">Ng SR</searchLink>; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore.<br /><searchLink fieldCode="AU" term="%22Yao+X%22">Yao X</searchLink>; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore.<br /><searchLink fieldCode="AU" term="%22Wee+FYT%22">Wee FYT</searchLink>; Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+JCT%22">Lim JCT</searchLink>; Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore.<br /><searchLink fieldCode="AU" term="%22Liu+W%22">Liu W</searchLink>; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xiao+R%22">Xiao R</searchLink>; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zeng+X%22">Zeng X</searchLink>; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Koh+J%22">Koh J</searchLink>; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore.<br /><searchLink fieldCode="AU" term="%22Kwek+XY%22">Kwek XY</searchLink>; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+CCY%22">Ng CCY</searchLink>; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Klanrit+P%22">Klanrit P</searchLink>; Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand.; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong.<br /><searchLink fieldCode="AU" term="%22Lai+J%22">Lai J</searchLink>; Department of Pancreaticobiliary Surgery, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Tai+DWM%22">Tai DWM</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Pairojkul+C%22">Pairojkul C</searchLink>; Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.<br /><searchLink fieldCode="AU" term="%22Dima+S%22">Dima S</searchLink>; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucuresti, Romania.<br /><searchLink fieldCode="AU" term="%22Popescu+I%22">Popescu I</searchLink>; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucuresti, Romania.<br /><searchLink fieldCode="AU" term="%22Hsieh+SY%22">Hsieh SY</searchLink>; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+MC%22">Yu MC</searchLink>; Department of General Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeong+J%22">Yeong J</searchLink>; Institute of Molecular and Cell Biology, Integrative Biology for Theranostics Lab, Agency for Science Technology and Research (A*STAR), Singapore.; Department of Anatomical Pathology, Singapore General Hospital, Singapore.; Pathology Academic Clinical Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Kongpetch+S%22">Kongpetch S</searchLink>; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.; Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.<br /><searchLink fieldCode="AU" term="%22Jusakul+A%22">Jusakul A</searchLink>; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.; Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.<br /><searchLink fieldCode="AU" term="%22Loilome+W%22">Loilome W</searchLink>; Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen, Thailand.; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.<br /><searchLink fieldCode="AU" term="%22Tan+P%22">Tan P</searchLink>; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+J%22">Tan J</searchLink>; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; State Key Laboratory of Oncology, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Teh+BT%22">Teh BT</searchLink>; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore teh.bin.tean@singhealth.com.sg.; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), Singapore.; Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore.
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