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Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors.

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Title: Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors.
Authors: Kazi A; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida., Ranjan A; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia., Kumar M V V; Department of Biochemistry, Department of Medicine, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York., Agianian B; Department of Biochemistry, Department of Medicine, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York., Garcia Chavez M; Department of Chemistry, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois., Vudatha V; Department of Surgery, Virginia Commonwealth University, Richmond, Virginia., Wang R; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia., Vangipurapu R; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida., Chen L; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida., Kennedy P; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida., Subramanian K; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia., Quirke JCK; Department of Chemistry, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois., Beato F; Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida., Underwood PW; Department of Surgery, University of Florida, Gainesville, Florida., Fleming JB; Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida., Trevino J; Department of Surgery, Virginia Commonwealth University, Richmond, Virginia.; Department of Surgery, University of Florida, Gainesville, Florida., Hergenrother PJ; Department of Chemistry, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois., Gavathiotis E; Department of Biochemistry, Department of Medicine, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York., Sebti SM; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida.
Source: Cancer research communications [Cancer Res Commun] 2023 Dec 28; Vol. 3 (12), pp. 2623-2639.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors.
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  Data: <searchLink fieldCode="AU" term="%22Kazi+A%22">Kazi A</searchLink>; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Ranjan+A%22">Ranjan A</searchLink>; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Kumar+M+V+V%22">Kumar M V V</searchLink>; Department of Biochemistry, Department of Medicine, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York.<br /><searchLink fieldCode="AU" term="%22Agianian+B%22">Agianian B</searchLink>; Department of Biochemistry, Department of Medicine, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York.<br /><searchLink fieldCode="AU" term="%22Garcia+Chavez+M%22">Garcia Chavez M</searchLink>; Department of Chemistry, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois.<br /><searchLink fieldCode="AU" term="%22Vudatha+V%22">Vudatha V</searchLink>; Department of Surgery, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Vangipurapu+R%22">Vangipurapu R</searchLink>; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Kennedy+P%22">Kennedy P</searchLink>; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Subramanian+K%22">Subramanian K</searchLink>; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia.<br /><searchLink fieldCode="AU" term="%22Quirke+JCK%22">Quirke JCK</searchLink>; Department of Chemistry, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois.<br /><searchLink fieldCode="AU" term="%22Beato+F%22">Beato F</searchLink>; Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Underwood+PW%22">Underwood PW</searchLink>; Department of Surgery, University of Florida, Gainesville, Florida.<br /><searchLink fieldCode="AU" term="%22Fleming+JB%22">Fleming JB</searchLink>; Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Trevino+J%22">Trevino J</searchLink>; Department of Surgery, Virginia Commonwealth University, Richmond, Virginia.; Department of Surgery, University of Florida, Gainesville, Florida.<br /><searchLink fieldCode="AU" term="%22Hergenrother+PJ%22">Hergenrother PJ</searchLink>; Department of Chemistry, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois.<br /><searchLink fieldCode="AU" term="%22Gavathiotis+E%22">Gavathiotis E</searchLink>; Department of Biochemistry, Department of Medicine, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York.<br /><searchLink fieldCode="AU" term="%22Sebti+SM%22">Sebti SM</searchLink>; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida.
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  Data: <searchLink fieldCode="JN" term="%229918281580506676%22">Cancer research communications</searchLink> [Cancer Res Commun] 2023 Dec 28; Vol. 3 (12), pp. 2623-2639.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918281580506676 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2767-9764 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227679764%22">27679764 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res Commun <i>Subsets: </i>MEDLINE
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