Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors.
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| Title: | Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors. |
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| Authors: | Kazi A; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida., Ranjan A; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia., Kumar M V V; Department of Biochemistry, Department of Medicine, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York., Agianian B; Department of Biochemistry, Department of Medicine, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York., Garcia Chavez M; Department of Chemistry, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois., Vudatha V; Department of Surgery, Virginia Commonwealth University, Richmond, Virginia., Wang R; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia., Vangipurapu R; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida., Chen L; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida., Kennedy P; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida., Subramanian K; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia., Quirke JCK; Department of Chemistry, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois., Beato F; Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida., Underwood PW; Department of Surgery, University of Florida, Gainesville, Florida., Fleming JB; Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida., Trevino J; Department of Surgery, Virginia Commonwealth University, Richmond, Virginia.; Department of Surgery, University of Florida, Gainesville, Florida., Hergenrother PJ; Department of Chemistry, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois., Gavathiotis E; Department of Biochemistry, Department of Medicine, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York., Sebti SM; Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida. |
| Source: | Cancer research communications [Cancer Res Commun] 2023 Dec 28; Vol. 3 (12), pp. 2623-2639. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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