Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats.

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Title: Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats.
Authors: Jiang W; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Glaeser JD; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Kaneda G; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Sheyn J; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Wechsler JT; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Stephan S; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Salehi K; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Chan JL; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Tawackoli W; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Avalos P; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Johnson C; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Castaneda C; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Kanim LEA; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Tanasansomboon T; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Center of Excellence in Biomechanics and Innovative Spine Surgery, Department of Orthopedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Burda JE; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Shelest O; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Yameen H; Department of Biomedical Engineering, Israeli Institute of Technology Technion, Haifa 3200003, Israel., Perry TG; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Kropf M; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Cuellar JM; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Seliktar D; Department of Biomedical Engineering, Israeli Institute of Technology Technion, Haifa 3200003, Israel., Bae HW; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Stone LS; Department of Biomedical Engineering, Israeli Institute of Technology Technion, Haifa 3200003, Israel., Sheyn D; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Source: Science translational medicine [Sci Transl Med] 2023 Dec 06; Vol. 15 (725), pp. eadg7020. Date of Electronic Publication: 2023 Dec 06.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats.
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  Data: <searchLink fieldCode="AU" term="%22Jiang+W%22">Jiang W</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Glaeser+JD%22">Glaeser JD</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Kaneda+G%22">Kaneda G</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Sheyn+J%22">Sheyn J</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Wechsler+JT%22">Wechsler JT</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Stephan+S%22">Stephan S</searchLink>; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Salehi+K%22">Salehi K</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Chan+JL%22">Chan JL</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Tawackoli+W%22">Tawackoli W</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Avalos+P%22">Avalos P</searchLink>; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+C%22">Johnson C</searchLink>; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Castaneda+C%22">Castaneda C</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Kanim+LEA%22">Kanim LEA</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Tanasansomboon+T%22">Tanasansomboon T</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Center of Excellence in Biomechanics and Innovative Spine Surgery, Department of Orthopedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Burda+JE%22">Burda JE</searchLink>; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Shelest+O%22">Shelest O</searchLink>; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Yameen+H%22">Yameen H</searchLink>; Department of Biomedical Engineering, Israeli Institute of Technology Technion, Haifa 3200003, Israel.<br /><searchLink fieldCode="AU" term="%22Perry+TG%22">Perry TG</searchLink>; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Kropf+M%22">Kropf M</searchLink>; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Cuellar+JM%22">Cuellar JM</searchLink>; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Seliktar+D%22">Seliktar D</searchLink>; Department of Biomedical Engineering, Israeli Institute of Technology Technion, Haifa 3200003, Israel.<br /><searchLink fieldCode="AU" term="%22Bae+HW%22">Bae HW</searchLink>; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.<br /><searchLink fieldCode="AU" term="%22Stone+LS%22">Stone LS</searchLink>; Department of Biomedical Engineering, Israeli Institute of Technology Technion, Haifa 3200003, Israel.<br /><searchLink fieldCode="AU" term="%22Sheyn+D%22">Sheyn D</searchLink>; Orthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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