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Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2.

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Title: Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2.
Authors: Gu Y; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUH-Cambridge Immune Phenotyping Centre, National University of Singapore, Singapore, Singapore., Shunmuganathan B; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Qian X; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Gupta R; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan RSW; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Kozma M; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Purushotorman K; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Murali TM; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan NYJ; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Preiser PR; Antimicrobial Resistance Interdisciplinary Research Group (AMR-IRG), Singapore-MIT Alliance in Research and Technology (SMART), Singapore, 138602, Singapore.; School of Biological Science (SBS), Nanyang Technological University (NTU), 60 Nanyang Dr, Singapore, 637551, Singapore., Lescar J; School of Biological Science (SBS), Nanyang Technological University (NTU), 60 Nanyang Dr, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore, 636921, Singapore., Nasir H; Division of Infectious Disease, University Medicine Cluster, National University Hospital, Singapore, Singapore., Somani J; Division of Infectious Disease, University Medicine Cluster, National University Hospital, Singapore, Singapore., Tambyah PA; Division of Infectious Disease, University Medicine Cluster, National University Hospital, Singapore, Singapore., Smith KGC; NUH-Cambridge Immune Phenotyping Centre, National University of Singapore, Singapore, Singapore.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Renia L; A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Ng LFP; A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lye DC; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases (NCID), Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Young BE; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases (NCID), Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore., MacAry PA; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.; NUH-Cambridge Immune Phenotyping Centre, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.
Corporate Authors: SCOPE Cohort Study Group
Source: Scientific reports [Sci Rep] 2023 Dec 09; Vol. 13 (1), pp. 21810. Date of Electronic Publication: 2023 Dec 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2.
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  Data: <searchLink fieldCode="AU" term="%22Gu+Y%22">Gu Y</searchLink>; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUH-Cambridge Immune Phenotyping Centre, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Shunmuganathan+B%22">Shunmuganathan B</searchLink>; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Qian+X%22">Qian X</searchLink>; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Gupta+R%22">Gupta R</searchLink>; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+RSW%22">Tan RSW</searchLink>; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kozma+M%22">Kozma M</searchLink>; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Purushotorman+K%22">Purushotorman K</searchLink>; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Murali+TM%22">Murali TM</searchLink>; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+NYJ%22">Tan NYJ</searchLink>; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Preiser+PR%22">Preiser PR</searchLink>; Antimicrobial Resistance Interdisciplinary Research Group (AMR-IRG), Singapore-MIT Alliance in Research and Technology (SMART), Singapore, 138602, Singapore.; School of Biological Science (SBS), Nanyang Technological University (NTU), 60 Nanyang Dr, Singapore, 637551, Singapore.<br /><searchLink fieldCode="AU" term="%22Lescar+J%22">Lescar J</searchLink>; School of Biological Science (SBS), Nanyang Technological University (NTU), 60 Nanyang Dr, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore, 636921, Singapore.<br /><searchLink fieldCode="AU" term="%22Nasir+H%22">Nasir H</searchLink>; Division of Infectious Disease, University Medicine Cluster, National University Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Somani+J%22">Somani J</searchLink>; Division of Infectious Disease, University Medicine Cluster, National University Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tambyah+PA%22">Tambyah PA</searchLink>; Division of Infectious Disease, University Medicine Cluster, National University Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Smith+KGC%22">Smith KGC</searchLink>; NUH-Cambridge Immune Phenotyping Centre, National University of Singapore, Singapore, Singapore.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Renia+L%22">Renia L</searchLink>; A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+LFP%22">Ng LFP</searchLink>; A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lye+DC%22">Lye DC</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases (NCID), Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Young+BE%22">Young BE</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases (NCID), Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22MacAry+PA%22">MacAry PA</searchLink>; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.; NUH-Cambridge Immune Phenotyping Centre, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2023 Dec 09; Vol. 13 (1), pp. 21810. <i>Date of Electronic Publication: </i>2023 Dec 09.
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