Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.
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| Title: | Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment. |
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| Authors: | Madorsky Rowdo FP; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, NY10021., Xiao G; The Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021., Khramtsova GF; Center for Clinical Cancer Genetics and Global Health and Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637., Nguyen J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, NY10021., Olopade OI; Center for Clinical Cancer Genetics and Global Health and Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637., Martini R; Department of Surgery, Weill Cornell Medicine, New York, NY10021., Stonaker B; Department of Surgery, Weill Cornell Medicine, New York, NY10021., Boateng R; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Oppong JK; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Adjei EK; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Awuah B; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Kyei I; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Aitpillah FS; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Adinku MO; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Ankomah K; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Osei-Bonsu EB; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Gyan KK; Department of Surgery, Weill Cornell Medicine, New York, NY10021., Altorki NK; Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY., Cheng E; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY., Ginter PS; Department of Pathology, NYU Langone Hospital-Long Island, Mineola, NY., Hoda S; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY., Newman L; Department of Surgery, Weill Cornell Medicine, New York, NY10021., Elemento O; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, NY10021., Davis MB; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, NY10021.; Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive, Atlanta, GA 30310., Martin ML; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, NY10021., Bargonetti J; The Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York City, NY 10021.; The Graduate Center Biology and Biochemistry Programs of City University of New York, New York, NY 10016. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 22. Date of Electronic Publication: 2023 Jun 22. |
| Publication Type: | Preprint; Journal Article |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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