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Efficacy and toxicity of bimodal radiotherapy in WHO grade 2 meningiomas following subtotal resection with carbon ion boost: Prospective phase 2 MARCIE trial.

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Title: Efficacy and toxicity of bimodal radiotherapy in WHO grade 2 meningiomas following subtotal resection with carbon ion boost: Prospective phase 2 MARCIE trial.
Authors: Deng MY; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany., Maas SLN; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands., Hinz F; Department of Neuropathology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Karger CP; Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany., Sievers P; Department of Neuropathology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Eichkorn T; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Meixner E; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany., Hoegen-Sassmannshausen P; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany., Hörner-Rieber J; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany., Lischalk JW; Department of Radiation Oncology, Perlmutter Cancer Center at New York University Langone Health at Long Island, New York, New York, USA., Seidensaal K; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany., Bernhardt D; Department of Radiation Oncology, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany., Jungk C; Department of Neurosurgery, University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany., Unterberg A; Department of Neurosurgery, University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany., Wick A; Department of Neurology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany., Wick W; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Neurology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., von Deimling A; Department of Neuropathology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Sahm F; Department of Neuropathology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Combs S; Department of Radiation Oncology, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany., Herfarth K; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany., Debus J; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany., König L; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.
Source: Neuro-oncology [Neuro Oncol] 2024 Apr 05; Vol. 26 (4), pp. 701-712.
Publication Type: Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and toxicity of bimodal radiotherapy in WHO grade 2 meningiomas following subtotal resection with carbon ion boost: Prospective phase 2 MARCIE trial.
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  Data: <searchLink fieldCode="AU" term="%22Deng+MY%22">Deng MY</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Maas+SLN%22">Maas SLN</searchLink>; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hinz+F%22">Hinz F</searchLink>; Department of Neuropathology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Karger+CP%22">Karger CP</searchLink>; Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sievers+P%22">Sievers P</searchLink>; Department of Neuropathology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Eichkorn+T%22">Eichkorn T</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Meixner+E%22">Meixner E</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hoegen-Sassmannshausen+P%22">Hoegen-Sassmannshausen P</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hörner-Rieber+J%22">Hörner-Rieber J</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lischalk+JW%22">Lischalk JW</searchLink>; Department of Radiation Oncology, Perlmutter Cancer Center at New York University Langone Health at Long Island, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Seidensaal+K%22">Seidensaal K</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bernhardt+D%22">Bernhardt D</searchLink>; Department of Radiation Oncology, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jungk+C%22">Jungk C</searchLink>; Department of Neurosurgery, University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Unterberg+A%22">Unterberg A</searchLink>; Department of Neurosurgery, University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wick+A%22">Wick A</searchLink>; Department of Neurology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wick+W%22">Wick W</searchLink>; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Neurology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22von+Deimling+A%22">von Deimling A</searchLink>; Department of Neuropathology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sahm+F%22">Sahm F</searchLink>; Department of Neuropathology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Combs+S%22">Combs S</searchLink>; Department of Radiation Oncology, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Herfarth+K%22">Herfarth K</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Debus+J%22">Debus J</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22König+L%22">König L</searchLink>; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.
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