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Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction.

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Title: Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction.
Authors: Jorge SD; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States., Chi YI; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States., Mazaba JL; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States., Haque N; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States., Wagenknecht J; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States., Smith BC; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, United States., Volkman BF; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, United States., Mathison AJ; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States., Lomberk G; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States., Zimmermann MT; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, United States.; Clinical and Translational Sciences Institute, Medical College of Wisconsin, Milwaukee, WI, United States., Urrutia R; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, United States.
Source: Frontiers in genetics [Front Genet] 2023 Nov 28; Vol. 14, pp. 1291307. Date of Electronic Publication: 2023 Nov 28 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101560621 Publication Model: eCollection Cited Medium: Print ISSN: 1664-8021 (Print) Linking ISSN: 16648021 NLM ISO Abbreviation: Front Genet Subsets: PubMed not MEDLINE
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