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Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain.

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Title: Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain.
Authors: Somersan-Karakaya S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Turner KC; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Cortes-Burgos L; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Miller J; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., LaCroix-Fralish M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Logovinsky V; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Patel Y; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Torres R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Ganguly S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Breazna A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., DeVeaux M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Bhore R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Gao M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Delfino FJ; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Rafique A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Fairhurst JL; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Hunt C; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Babb R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Badithe A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Poueymirou WT; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Surowitz R; Health Awareness, Jupiter, FL, United States., Rottey S; Ghent University Hospital, Ghent, Belgium., Murphy AJ; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Harari O; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Macdonald LE; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Croll SD; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.
Source: Neurobiology of pain (Cambridge, Mass.) [Neurobiol Pain] 2023 Jun 26; Vol. 14, pp. 100136. Date of Electronic Publication: 2023 Jun 26 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 101705141 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-073X (Electronic) Linking ISSN: 2452073X NLM ISO Abbreviation: Neurobiol Pain Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2452-073X
DOI:10.1016/j.ynpai.2023.100136