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Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain.

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Title: Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain.
Authors: Somersan-Karakaya S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Turner KC; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Cortes-Burgos L; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Miller J; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., LaCroix-Fralish M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Logovinsky V; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Patel Y; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Torres R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Ganguly S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Breazna A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., DeVeaux M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Bhore R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Gao M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Delfino FJ; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Rafique A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Fairhurst JL; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Hunt C; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Babb R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Badithe A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Poueymirou WT; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Surowitz R; Health Awareness, Jupiter, FL, United States., Rottey S; Ghent University Hospital, Ghent, Belgium., Murphy AJ; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Harari O; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Macdonald LE; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States., Croll SD; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.
Source: Neurobiology of pain (Cambridge, Mass.) [Neurobiol Pain] 2023 Jun 26; Vol. 14, pp. 100136. Date of Electronic Publication: 2023 Jun 26 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 101705141 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-073X (Electronic) Linking ISSN: 2452073X NLM ISO Abbreviation: Neurobiol Pain Subsets: PubMed not MEDLINE
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  Data: Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain.
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  Data: <searchLink fieldCode="AU" term="%22Somersan-Karakaya+S%22">Somersan-Karakaya S</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Turner+KC%22">Turner KC</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Cortes-Burgos+L%22">Cortes-Burgos L</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Miller+J%22">Miller J</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22LaCroix-Fralish+M%22">LaCroix-Fralish M</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Logovinsky+V%22">Logovinsky V</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Patel+Y%22">Patel Y</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Torres+R%22">Torres R</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Ganguly+S%22">Ganguly S</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Breazna+A%22">Breazna A</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22DeVeaux+M%22">DeVeaux M</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Bhore+R%22">Bhore R</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Gao+M%22">Gao M</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Delfino+FJ%22">Delfino FJ</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Rafique+A%22">Rafique A</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Fairhurst+JL%22">Fairhurst JL</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Hunt+C%22">Hunt C</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Babb+R%22">Babb R</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Badithe+A%22">Badithe A</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Poueymirou+WT%22">Poueymirou WT</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Surowitz+R%22">Surowitz R</searchLink>; Health Awareness, Jupiter, FL, United States.<br /><searchLink fieldCode="AU" term="%22Rottey+S%22">Rottey S</searchLink>; Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Murphy+AJ%22">Murphy AJ</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Harari+O%22">Harari O</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Macdonald+LE%22">Macdonald LE</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.<br /><searchLink fieldCode="AU" term="%22Croll+SD%22">Croll SD</searchLink>; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States.
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