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Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile.

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Title: Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile.
Authors: Cun WY; School of Chemistry and Molecular Bioscience, Molecular Horizons Research Institute, University of Wollongong, Wollongong 2522 New South Wales, Australia., Bate CE; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia., Srikhanta YN; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia., Hutton ML; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia., Webb CT; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia., Revitt-Mills SA; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia., Lyras D; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia., McGowan S; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia., Yu H; School of Chemistry and Molecular Bioscience, Molecular Horizons Research Institute, University of Wollongong, Wollongong 2522 New South Wales, Australia.; ARC Centre of Excellence in Quantum Biotechnology, University of Wollongong, Wollongong 2522 New South Wales, Australia., Keller PA; School of Chemistry and Molecular Bioscience, Molecular Horizons Research Institute, University of Wollongong, Wollongong 2522 New South Wales, Australia., Pyne SG; School of Chemistry and Molecular Bioscience, Molecular Horizons Research Institute, University of Wollongong, Wollongong 2522 New South Wales, Australia.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Jan 11; Vol. 67 (1), pp. 450-466. Date of Electronic Publication: 2023 Dec 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile.
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  Data: <searchLink fieldCode="AU" term="%22Cun+WY%22">Cun WY</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons Research Institute, University of Wollongong, Wollongong 2522 New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Bate+CE%22">Bate CE</searchLink>; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia.<br /><searchLink fieldCode="AU" term="%22Srikhanta+YN%22">Srikhanta YN</searchLink>; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia.<br /><searchLink fieldCode="AU" term="%22Hutton+ML%22">Hutton ML</searchLink>; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia.<br /><searchLink fieldCode="AU" term="%22Webb+CT%22">Webb CT</searchLink>; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia.<br /><searchLink fieldCode="AU" term="%22Revitt-Mills+SA%22">Revitt-Mills SA</searchLink>; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia.<br /><searchLink fieldCode="AU" term="%22Lyras+D%22">Lyras D</searchLink>; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia.<br /><searchLink fieldCode="AU" term="%22McGowan+S%22">McGowan S</searchLink>; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia.; Centre to Impact AMR, Monash University, Clayton 3800, Victoria Australia.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons Research Institute, University of Wollongong, Wollongong 2522 New South Wales, Australia.; ARC Centre of Excellence in Quantum Biotechnology, University of Wollongong, Wollongong 2522 New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Keller+PA%22">Keller PA</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons Research Institute, University of Wollongong, Wollongong 2522 New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Pyne+SG%22">Pyne SG</searchLink>; School of Chemistry and Molecular Bioscience, Molecular Horizons Research Institute, University of Wollongong, Wollongong 2522 New South Wales, Australia.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Jan 11; Vol. 67 (1), pp. 450-466. <i>Date of Electronic Publication: </i>2023 Dec 19.
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        Value: 10.1021/acs.jmedchem.3c01662
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              Text: 2024 Jan 11
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