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Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes.

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Title: Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes.
Authors: Isobe T; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Kucinski I; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Barile M; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Wang X; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Hannah R; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Bastos HP; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Chabra S; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Vijayabaskar MS; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Sturgess KHM; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Williams MJ; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Giotopoulos G; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Marando L; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Li J; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Rak J; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; Hematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Gozdecka M; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; Hematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Prins D; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Shepherd MS; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Watcham S; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Green AR; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Kent DG; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; York Biomedical Research Institute, Department of Biology, University of York, York, UK., Vassiliou GS; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; Hematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Huntly BJP; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK., Wilson NK; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK. Electronic address: nkw22@cam.ac.uk., Göttgens B; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK. Electronic address: bg200@cam.ac.uk.
Source: Cell genomics [Cell Genom] 2023 Oct 27; Vol. 3 (12), pp. 100426. Date of Electronic Publication: 2023 Oct 27 (Print Publication: 2023).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: MEDLINE; PubMed not MEDLINE
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  Data: Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes.
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  Data: <searchLink fieldCode="AU" term="%22Isobe+T%22">Isobe T</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kucinski+I%22">Kucinski I</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Barile+M%22">Barile M</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hannah+R%22">Hannah R</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bastos+HP%22">Bastos HP</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Chabra+S%22">Chabra S</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vijayabaskar+MS%22">Vijayabaskar MS</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sturgess+KHM%22">Sturgess KHM</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Williams+MJ%22">Williams MJ</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Giotopoulos+G%22">Giotopoulos G</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Marando+L%22">Marando L</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rak+J%22">Rak J</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; Hematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; Hematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Prins+D%22">Prins D</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Shepherd+MS%22">Shepherd MS</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Watcham+S%22">Watcham S</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Green+AR%22">Green AR</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kent+DG%22">Kent DG</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; York Biomedical Research Institute, Department of Biology, University of York, York, UK.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK; Hematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Huntly+BJP%22">Huntly BJP</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wilson+NK%22">Wilson NK</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK. Electronic address: nkw22@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Göttgens+B%22">Göttgens B</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, Department of Hematology, University of Cambridge, Cambridge, UK. Electronic address: bg200@cam.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229918284260106676%22">Cell genomics</searchLink> [Cell Genom] 2023 Oct 27; Vol. 3 (12), pp. 100426. <i>Date of Electronic Publication: </i>2023 Oct 27 (<i>Print Publication: </i>2023).
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