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Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists.

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Title: Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists.
Authors: Thomson CG; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Boss K; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Calhoun A; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Fridrich C; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Gardinier KM; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Hall EC; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Jendza K; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Kirman L; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Labbé-Giguere N; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Laumen K; Global Discovery Chemistry, Novartis Biomedical Research, Basel CH-4002, Switzerland., Qian M; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Sanyal S; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Shultz MD; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Snajdrova R; Global Discovery Chemistry, Novartis Biomedical Research, Basel CH-4002, Switzerland., Tan K; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Wang KY; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Yang F; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Gao F; Chemical & Analytical Development, Suzhou, Novartis Technical Development, Co., Ltd., Changshu, Jiangsu 215537, P. R. China., Hong T; Chemical & Analytical Development, Suzhou, Novartis Technical Development, Co., Ltd., Changshu, Jiangsu 215537, P. R. China., Dale E; Neuroscience Disease Area, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Kuzmiski B; Neuroscience Disease Area, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Ortuno D; Neuroscience Disease Area, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Palacios DS; Global Discovery Chemistry, Novartis Biomedical Research, San Diego, California 92121, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Nov 06; Vol. 14 (12), pp. 1692-1699. Date of Electronic Publication: 2023 Nov 06 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists.
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  Data: <searchLink fieldCode="AU" term="%22Thomson+CG%22">Thomson CG</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Boss+K%22">Boss K</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Calhoun+A%22">Calhoun A</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Fridrich+C%22">Fridrich C</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Gardinier+KM%22">Gardinier KM</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Hall+EC%22">Hall EC</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Jendza+K%22">Jendza K</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Kirman+L%22">Kirman L</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Labbé-Giguere+N%22">Labbé-Giguere N</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Laumen+K%22">Laumen K</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Basel CH-4002, Switzerland.<br /><searchLink fieldCode="AU" term="%22Qian+M%22">Qian M</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Sanyal+S%22">Sanyal S</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Shultz+MD%22">Shultz MD</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Snajdrova+R%22">Snajdrova R</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Basel CH-4002, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tan+K%22">Tan K</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Wang+KY%22">Wang KY</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Yang+F%22">Yang F</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Gao+F%22">Gao F</searchLink>; Chemical & Analytical Development, Suzhou, Novartis Technical Development, Co., Ltd., Changshu, Jiangsu 215537, P. R. China.<br /><searchLink fieldCode="AU" term="%22Hong+T%22">Hong T</searchLink>; Chemical & Analytical Development, Suzhou, Novartis Technical Development, Co., Ltd., Changshu, Jiangsu 215537, P. R. China.<br /><searchLink fieldCode="AU" term="%22Dale+E%22">Dale E</searchLink>; Neuroscience Disease Area, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Kuzmiski+B%22">Kuzmiski B</searchLink>; Neuroscience Disease Area, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Ortuno+D%22">Ortuno D</searchLink>; Neuroscience Disease Area, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Palacios+DS%22">Palacios DS</searchLink>; Global Discovery Chemistry, Novartis Biomedical Research, San Diego, California 92121, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2023 Nov 06; Vol. 14 (12), pp. 1692-1699. <i>Date of Electronic Publication: </i>2023 Nov 06 (<i>Print Publication: </i>2023).
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