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Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.

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Title: Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
Authors: Elsayed MSA; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Blake JF; Computational Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Boys ML; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Brown E; Pharmacology, Pfizer-Boulder, Boulder, Colorado 80301, United States., Chapsal BD; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Chicarelli MJ; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Cook AW; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Fell JB; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Fischer JP; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Hanson L; Enzymology, Pfizer-Boulder, Boulder, Colorado 80301, United States., Lemieux C; Cellular Biology, Pfizer-Boulder, Boulder, Colorado 80301, United States., Martinson MC; Enzymology, Pfizer-Boulder, Boulder, Colorado 80301, United States., McCown J; ADME Sciences, Pfizer-Boulder, Boulder, Colorado 80301, United States., McNulty OT; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Mejia MJ; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Neitzel NA; DMPK, Pfizer-Boulder, Boulder, Colorado 80301, United States., Otten JN; ADME Sciences, Pfizer-Boulder, Boulder, Colorado 80301, United States., Rodriguez ME; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Wilcox D; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Wong CE; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Zhou Y; Structural Biology, Pfizer-Boulder, Boulder, Colorado 80301, United States., Hinklin RJ; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Nov 15; Vol. 14 (12), pp. 1673-1681. Date of Electronic Publication: 2023 Nov 15 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Elsayed+MSA%22">Elsayed MSA</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Blake+JF%22">Blake JF</searchLink>; Computational Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Boys+ML%22">Boys ML</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Brown+E%22">Brown E</searchLink>; Pharmacology, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Chapsal+BD%22">Chapsal BD</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Chicarelli+MJ%22">Chicarelli MJ</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Cook+AW%22">Cook AW</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Fell+JB%22">Fell JB</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Fischer+JP%22">Fischer JP</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Hanson+L%22">Hanson L</searchLink>; Enzymology, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Lemieux+C%22">Lemieux C</searchLink>; Cellular Biology, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Martinson+MC%22">Martinson MC</searchLink>; Enzymology, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22McCown+J%22">McCown J</searchLink>; ADME Sciences, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22McNulty+OT%22">McNulty OT</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Mejia+MJ%22">Mejia MJ</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Neitzel+NA%22">Neitzel NA</searchLink>; DMPK, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Otten+JN%22">Otten JN</searchLink>; ADME Sciences, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Rodriguez+ME%22">Rodriguez ME</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Wilcox+D%22">Wilcox D</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Wong+CE%22">Wong CE</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Structural Biology, Pfizer-Boulder, Boulder, Colorado 80301, United States.<br /><searchLink fieldCode="AU" term="%22Hinklin+RJ%22">Hinklin RJ</searchLink>; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2023 Nov 15; Vol. 14 (12), pp. 1673-1681. <i>Date of Electronic Publication: </i>2023 Nov 15 (<i>Print Publication: </i>2023).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101521073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1948-5875 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219485875%22">19485875 </searchLink><i>NLM ISO Abbreviation: </i>ACS Med Chem Lett <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2023 Nov 15
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