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Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses.

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Title: Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses.
Authors: Heinen N; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Khanal R; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.; Research Group RNA Therapeutics & Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany, Hannover Medical School, Hannover, Germany., Westhoven S; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Klöhn M; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Herrmann ST; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Herrmann M; Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany., Tuoc T; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany., Ulmke PA; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany., Nguyen HD; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany., Nguyen HP; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany., Steinmann E; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; German Centre for Infection Research (DZIF), External Partner Site, Bochum, Germany, Bochum, Germany., Todt D; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; European Virus Bioinformatics Center (EVBC), Jena, Germany., Brown RJP; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.; Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany., Sharma AD; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.; Research Group RNA Therapeutics & Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany, Hannover Medical School, Hannover, Germany., Pfaender S; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.
Source: Gut [Gut] 2024 Sep 09; Vol. 73 (10), pp. e14. Date of Electronic Publication: 2024 Sep 09.
Publication Type: Letter; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubTypeId: report
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  Data: Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses.
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  Data: <searchLink fieldCode="AU" term="%22Heinen+N%22">Heinen N</searchLink>; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Khanal+R%22">Khanal R</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.; Research Group RNA Therapeutics & Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Westhoven+S%22">Westhoven S</searchLink>; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Klöhn+M%22">Klöhn M</searchLink>; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Herrmann+ST%22">Herrmann ST</searchLink>; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Herrmann+M%22">Herrmann M</searchLink>; Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Tuoc+T%22">Tuoc T</searchLink>; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Ulmke+PA%22">Ulmke PA</searchLink>; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Nguyen+HD%22">Nguyen HD</searchLink>; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Nguyen+HP%22">Nguyen HP</searchLink>; Department of Human Genetics, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Steinmann+E%22">Steinmann E</searchLink>; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; German Centre for Infection Research (DZIF), External Partner Site, Bochum, Germany, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Todt+D%22">Todt D</searchLink>; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; European Virus Bioinformatics Center (EVBC), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Brown+RJP%22">Brown RJP</searchLink>; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.; Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Sharma+AD%22">Sharma AD</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.; Research Group RNA Therapeutics & Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Pfaender+S%22">Pfaender S</searchLink>; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22British+Medical+Assn%22">British Medical Assn </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985108R <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1468-3288 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200175749%22">00175749 </searchLink><i>NLM ISO Abbreviation: </i>Gut <i>Subsets: </i>MEDLINE
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        Value: 10.1136/gutjnl-2023-330961
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      – Code: eng
        Text: English
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              Text: 2024 Sep 09
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