p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
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| Title: | p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003. |
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| Authors: | Taylor LW; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Simzer EM; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Pimblett C; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK., Lacey-Solymar OTT; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK., McGeachan RI; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.; The Hospital for Small Animals, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK., Meftah S; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Rose JL; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Spires-Jones MP; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK., Holt K; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Catterson JH; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Koch H; Department of Neurology, Epileptology, RWTH Aachen University Hospital, 52074, Aachen, Germany., Liaquat I; Department of Clinical Neuroscience, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK., Clarke JH; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge, UK., Skidmore J; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge, UK., Smith C; The Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK., Booker SA; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Simons Initiative for the Developing Brain, The University of Edinburgh, Edinburgh, UK., Brennan PM; Department of Clinical Neuroscience, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK.; The Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Cancer Research UK Brain Tumour Centre of Excellence, CRUK Edinburgh Centre, The University of Edinburgh, Edinburgh, UK., Spires-Jones TL; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Durrant CS; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk. |
| Source: | Acta neuropathologica [Acta Neuropathol] 2024 Jan 04; Vol. 147 (1), pp. 7. Date of Electronic Publication: 2024 Jan 04. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-0533 |
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| DOI: | 10.1007/s00401-023-02667-w |
