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p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.

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Title: p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
Authors: Taylor LW; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Simzer EM; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Pimblett C; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK., Lacey-Solymar OTT; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK., McGeachan RI; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.; The Hospital for Small Animals, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK., Meftah S; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Rose JL; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Spires-Jones MP; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK., Holt K; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Catterson JH; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Koch H; Department of Neurology, Epileptology, RWTH Aachen University Hospital, 52074, Aachen, Germany., Liaquat I; Department of Clinical Neuroscience, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK., Clarke JH; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge, UK., Skidmore J; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge, UK., Smith C; The Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK., Booker SA; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Simons Initiative for the Developing Brain, The University of Edinburgh, Edinburgh, UK., Brennan PM; Department of Clinical Neuroscience, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK.; The Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Cancer Research UK Brain Tumour Centre of Excellence, CRUK Edinburgh Centre, The University of Edinburgh, Edinburgh, UK., Spires-Jones TL; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK., Durrant CS; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.
Source: Acta neuropathologica [Acta Neuropathol] 2024 Jan 04; Vol. 147 (1), pp. 7. Date of Electronic Publication: 2024 Jan 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
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  Data: <searchLink fieldCode="AU" term="%22Taylor+LW%22">Taylor LW</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Simzer+EM%22">Simzer EM</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Pimblett+C%22">Pimblett C</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Lacey-Solymar+OTT%22">Lacey-Solymar OTT</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22McGeachan+RI%22">McGeachan RI</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.; The Hospital for Small Animals, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Meftah+S%22">Meftah S</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Rose+JL%22">Rose JL</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Spires-Jones+MP%22">Spires-Jones MP</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Holt+K%22">Holt K</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Catterson+JH%22">Catterson JH</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Koch+H%22">Koch H</searchLink>; Department of Neurology, Epileptology, RWTH Aachen University Hospital, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Liaquat+I%22">Liaquat I</searchLink>; Department of Clinical Neuroscience, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Clarke+JH%22">Clarke JH</searchLink>; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Skidmore+J%22">Skidmore J</searchLink>; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Smith+C%22">Smith C</searchLink>; The Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Booker+SA%22">Booker SA</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Simons Initiative for the Developing Brain, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Brennan+PM%22">Brennan PM</searchLink>; Department of Clinical Neuroscience, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK.; The Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Cancer Research UK Brain Tumour Centre of Excellence, CRUK Edinburgh Centre, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Spires-Jones+TL%22">Spires-Jones TL</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Durrant+CS%22">Durrant CS</searchLink>; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2024 Jan 04; Vol. 147 (1), pp. 7. <i>Date of Electronic Publication: </i>2024 Jan 04.
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