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Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo.

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Title: Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo.
Authors: Liu M; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Zhang C; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Gong X; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Zhang T; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Lian MM; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, Singapore 138672, Singapore., Chew EGY; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, Singapore 138672, Singapore., Cardilla A; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Suzuki K; Institute for Advanced Co-Creation Studies, Osaka University, Toyonaka 560-8531, Osaka, Japan; Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Osaka, Japan; Graduate School of Frontier Bioscience, Osaka University, Suita 560-8531, Osaka, Japan., Wang H; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Yuan Y; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore; Institute of Special Environmental Medicine, Nantong University, Nantong 226019, Jiangsu, China., Li Y; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Naik MY; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Wang Y; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Zhou B; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Soon WZ; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Aizawa E; Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Osaka, Japan., Li P; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Low JH; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore., Tandiono M; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, Singapore 138672, Singapore., Montagud E; Hospital Clinic of Barcelona, Career Villarroel, 170, 08036 Barcelona, Spain., Moya-Rull D; Pluripotency for Organ Regeneration (PR Lab), Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain., Rodriguez Esteban C; Altos Labs, 5510 Morehouse Drive, Suite 300, San Diego, CA 92121, USA., Luque Y; Hospital Clinic of Barcelona, Career Villarroel, 170, 08036 Barcelona, Spain., Fang M; Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China., Khor CC; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, Singapore 138672, Singapore; Duke-National University of Singapore Medical School, 8 College Road, Singapore 169857, Singapore; Singapore Eye Research Institute, 20 College Road Discovery Tower, Level 6 The Academia, Singapore 169856, Singapore., Montserrat N; Pluripotency for Organ Regeneration (PR Lab), Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; University of Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig de Lluís Companys, 23, 08010 Barcelona, Spain; Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain., Campistol JM; Hospital Clinic of Barcelona, Career Villarroel, 170, 08036 Barcelona, Spain., Izpisua Belmonte JC; Altos Labs, 5510 Morehouse Drive, Suite 300, San Diego, CA 92121, USA. Electronic address: jcbelmonte@altoslabs.com., Foo JN; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, Singapore 138672, Singapore. Electronic address: jianee.foo@ntu.edu.sg., Xia Y; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore. Electronic address: yunxia@ntu.edu.sg.
Source: Cell stem cell [Cell Stem Cell] 2024 Jan 04; Vol. 31 (1), pp. 52-70.e8.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE
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  Data: Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo.
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  Data: <searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Gong+X%22">Gong X</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Lian+MM%22">Lian MM</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Chew+EGY%22">Chew EGY</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Cardilla+A%22">Cardilla A</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; Institute for Advanced Co-Creation Studies, Osaka University, Toyonaka 560-8531, Osaka, Japan; Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Osaka, Japan; Graduate School of Frontier Bioscience, Osaka University, Suita 560-8531, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore; Institute of Special Environmental Medicine, Nantong University, Nantong 226019, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Naik+MY%22">Naik MY</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhou+B%22">Zhou B</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Soon+WZ%22">Soon WZ</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Aizawa+E%22">Aizawa E</searchLink>; Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Low+JH%22">Low JH</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Tandiono+M%22">Tandiono M</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Montagud+E%22">Montagud E</searchLink>; Hospital Clinic of Barcelona, Career Villarroel, 170, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Moya-Rull+D%22">Moya-Rull D</searchLink>; Pluripotency for Organ Regeneration (PR Lab), Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodriguez+Esteban+C%22">Rodriguez Esteban C</searchLink>; Altos Labs, 5510 Morehouse Drive, Suite 300, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Luque+Y%22">Luque Y</searchLink>; Hospital Clinic of Barcelona, Career Villarroel, 170, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fang+M%22">Fang M</searchLink>; Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China.<br /><searchLink fieldCode="AU" term="%22Khor+CC%22">Khor CC</searchLink>; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, Singapore 138672, Singapore; Duke-National University of Singapore Medical School, 8 College Road, Singapore 169857, Singapore; Singapore Eye Research Institute, 20 College Road Discovery Tower, Level 6 The Academia, Singapore 169856, Singapore.<br /><searchLink fieldCode="AU" term="%22Montserrat+N%22">Montserrat N</searchLink>; Pluripotency for Organ Regeneration (PR Lab), Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; University of Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig de Lluís Companys, 23, 08010 Barcelona, Spain; Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Campistol+JM%22">Campistol JM</searchLink>; Hospital Clinic of Barcelona, Career Villarroel, 170, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Izpisua+Belmonte+JC%22">Izpisua Belmonte JC</searchLink>; Altos Labs, 5510 Morehouse Drive, Suite 300, San Diego, CA 92121, USA. Electronic address: jcbelmonte@altoslabs.com.<br /><searchLink fieldCode="AU" term="%22Foo+JN%22">Foo JN</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, A∗STAR, Singapore 138672, Singapore. Electronic address: jianee.foo@ntu.edu.sg.<br /><searchLink fieldCode="AU" term="%22Xia+Y%22">Xia Y</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore. Electronic address: yunxia@ntu.edu.sg.
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