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Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.

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Title: Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.
Authors: Madorsky Rowdo FP; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Xiao G; The Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY, 10021, USA., Khramtsova GF; Center for Clinical Cancer Genetics and Global Health and Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, 60637, USA., Nguyen J; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Martini R; Department of Surgery, Weill Cornell Medicine, New York, NY, 10021, USA., Stonaker B; Department of Surgery, Weill Cornell Medicine, New York, NY, 10021, USA., Boateng R; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Oppong JK; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Adjei EK; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Awuah B; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Kyei I; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Aitpillah FS; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Adinku MO; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Ankomah K; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Osei-Bonsu EB; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Gyan KK; Department of Surgery, Weill Cornell Medicine, New York, NY, 10021, USA., Altorki NK; Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY, USA., Cheng E; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Ginter PS; Department of Pathology, NYU Langone Hospital-Long Island, Mineola, NY, USA., Hoda S; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Newman L; Department of Surgery, Weill Cornell Medicine, New York, NY, 10021, USA., Elemento O; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Olopade OI; Center for Clinical Cancer Genetics and Global Health and Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, 60637, USA., Davis MB; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA; Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive, Atlanta, GA, 30310, USA., Martin ML; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Bargonetti J; The Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY, 10021, USA; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York City, NY, 10021, USA; The Graduate Center Biology and Biochemistry Programs of City University of New York, New York, NY, 10016, USA. Electronic address: bargonetti@genectr.hunter.cuny.edu.
Source: Cancer letters [Cancer Lett] 2024 Mar 01; Vol. 584, pp. 216608. Date of Electronic Publication: 2024 Jan 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.
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  Data: <searchLink fieldCode="AU" term="%22Madorsky+Rowdo+FP%22">Madorsky Rowdo FP</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+G%22">Xiao G</searchLink>; The Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Khramtsova+GF%22">Khramtsova GF</searchLink>; Center for Clinical Cancer Genetics and Global Health and Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+J%22">Nguyen J</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Martini+R%22">Martini R</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Stonaker+B%22">Stonaker B</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Boateng+R%22">Boateng R</searchLink>; Komfo Anokye Teaching Hospital, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Oppong+JK%22">Oppong JK</searchLink>; Komfo Anokye Teaching Hospital, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Adjei+EK%22">Adjei EK</searchLink>; Komfo Anokye Teaching Hospital, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Awuah+B%22">Awuah B</searchLink>; Komfo Anokye Teaching Hospital, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Kyei+I%22">Kyei I</searchLink>; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Aitpillah+FS%22">Aitpillah FS</searchLink>; Komfo Anokye Teaching Hospital, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Adinku+MO%22">Adinku MO</searchLink>; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Ankomah+K%22">Ankomah K</searchLink>; Komfo Anokye Teaching Hospital, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Osei-Bonsu+EB%22">Osei-Bonsu EB</searchLink>; Komfo Anokye Teaching Hospital, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Gyan+KK%22">Gyan KK</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Altorki+NK%22">Altorki NK</searchLink>; Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+E%22">Cheng E</searchLink>; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ginter+PS%22">Ginter PS</searchLink>; Department of Pathology, NYU Langone Hospital-Long Island, Mineola, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hoda+S%22">Hoda S</searchLink>; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Newman+L%22">Newman L</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Elemento+O%22">Elemento O</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Olopade+OI%22">Olopade OI</searchLink>; Center for Clinical Cancer Genetics and Global Health and Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.<br /><searchLink fieldCode="AU" term="%22Davis+MB%22">Davis MB</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA; Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive, Atlanta, GA, 30310, USA.<br /><searchLink fieldCode="AU" term="%22Martin+ML%22">Martin ML</searchLink>; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Bargonetti+J%22">Bargonetti J</searchLink>; The Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY, 10021, USA; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York City, NY, 10021, USA; The Graduate Center Biology and Biochemistry Programs of City University of New York, New York, NY, 10016, USA. Electronic address: bargonetti@genectr.hunter.cuny.edu.
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  Data: <searchLink fieldCode="JN" term="%227600053%22">Cancer letters</searchLink> [Cancer Lett] 2024 Mar 01; Vol. 584, pp. 216608. <i>Date of Electronic Publication: </i>2024 Jan 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ireland%22">Elsevier Science Ireland </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7600053 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7980 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203043835%22">03043835 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Lett <i>Subsets: </i>MEDLINE
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