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Small Molecule Benzothiophene with In Vivo Efficacy in a Mouse Model of Drug-Resistant Enterococcus faecium Infection.

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Title: Small Molecule Benzothiophene with In Vivo Efficacy in a Mouse Model of Drug-Resistant Enterococcus faecium Infection.
Authors: Gallardo-Macias R; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Russo R; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States., Sherwood M; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Jaskowski M; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Nasser W; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Sharma P; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Tuckman M; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States., Singleton E; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States., Ho HP; Public Health Research Institute, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Park S; Public Health Research Institute, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Patel JS; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., George A; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Perlin D; Public Health Research Institute, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Zimmerman MD; Public Health Research Institute, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Connell N; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States., Freundlich JS; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Jan 25; Vol. 67 (2), pp. 1384-1392. Date of Electronic Publication: 2024 Jan 15.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Gallardo-Macias+R%22">Gallardo-Macias R</searchLink>; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22Russo+R%22">Russo R</searchLink>; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Sherwood+M%22">Sherwood M</searchLink>; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22Jaskowski+M%22">Jaskowski M</searchLink>; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22Nasser+W%22">Nasser W</searchLink>; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22Sharma+P%22">Sharma P</searchLink>; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22Tuckman+M%22">Tuckman M</searchLink>; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Singleton+E%22">Singleton E</searchLink>; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Ho+HP%22">Ho HP</searchLink>; Public Health Research Institute, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Public Health Research Institute, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22Patel+JS%22">Patel JS</searchLink>; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22George+A%22">George A</searchLink>; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22Perlin+D%22">Perlin D</searchLink>; Public Health Research Institute, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22Zimmerman+MD%22">Zimmerman MD</searchLink>; Public Health Research Institute, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.<br /><searchLink fieldCode="AU" term="%22Connell+N%22">Connell N</searchLink>; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Freundlich+JS%22">Freundlich JS</searchLink>; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark 07103, New Jersey, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Jan 25; Vol. 67 (2), pp. 1384-1392. <i>Date of Electronic Publication: </i>2024 Jan 15.
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