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Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.

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Title: Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.
Authors: Devine K; BHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Russell CD; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK., Blanco GR; Edinburgh Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Walker BR; BHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Homer NZM; BHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.; Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Denham SG; Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Simpson JP; Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Leavy OC; Department of Population Health Sciences, University of Leicester, Leicester, UK., Elneima O; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., McAuley HJC; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Shikotra A; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Singapuri A; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Sereno M; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Saunders RM; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Harris VC; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Houchen-Wolloff L; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Greening NJ; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Lone NI; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK., Thorpe M; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK., Greenhalf W; University of Liverpool, Liverpool, UK., Chalmers JD; Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Ho LP; MRC Human Immunology Unit, University of Oxford, Oxford, UK., Horsley A; Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Marks M; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.; Hospital for Tropical Diseases, University College London Hospital, London, UK.; Division of Infection and Immunity, University College London, London, UK., Raman B; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Moore SC; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK., Dunning J; Pandemic Sciences Institute, University of Oxford, Oxford, UK., Semple MG; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK., Andrew R; BHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.; Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Wain LV; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Evans RA; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Brightling CE; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Kenneth Baillie J; Division of Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, UK., Reynolds RM; BHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.
Corporate Authors: ISARIC4C Investigators and PHOSP-COVID Study Collaborative Group
Source: Clinical endocrinology [Clin Endocrinol (Oxf)] 2024 Apr; Vol. 100 (4), pp. 317-327. Date of Electronic Publication: 2024 Jan 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Blackwell Publishing Country of Publication: England NLM ID: 0346653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2265 (Electronic) Linking ISSN: 03000664 NLM ISO Abbreviation: Clin Endocrinol (Oxf) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Devine+K%22">Devine K</searchLink>; BHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Russell+CD%22">Russell CD</searchLink>; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Blanco+GR%22">Blanco GR</searchLink>; Edinburgh Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Walker+BR%22">Walker BR</searchLink>; BHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Homer+NZM%22">Homer NZM</searchLink>; BHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.; Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Denham+SG%22">Denham SG</searchLink>; Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Simpson+JP%22">Simpson JP</searchLink>; Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Leavy+OC%22">Leavy OC</searchLink>; Department of Population Health Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Elneima+O%22">Elneima O</searchLink>; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22McAuley+HJC%22">McAuley HJC</searchLink>; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Shikotra+A%22">Shikotra A</searchLink>; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Singapuri+A%22">Singapuri A</searchLink>; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Sereno+M%22">Sereno M</searchLink>; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Saunders+RM%22">Saunders RM</searchLink>; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Harris+VC%22">Harris VC</searchLink>; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Houchen-Wolloff+L%22">Houchen-Wolloff L</searchLink>; 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Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Marks+M%22">Marks M</searchLink>; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.; Hospital for Tropical Diseases, University College London Hospital, London, UK.; Division of Infection and Immunity, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Raman+B%22">Raman B</searchLink>; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Moore+SC%22">Moore SC</searchLink>; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Dunning+J%22">Dunning J</searchLink>; Pandemic Sciences Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Semple+MG%22">Semple MG</searchLink>; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Andrew+R%22">Andrew R</searchLink>; BHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.; Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wain+LV%22">Wain LV</searchLink>; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Evans+RA%22">Evans RA</searchLink>; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Brightling+CE%22">Brightling CE</searchLink>; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Kenneth+Baillie+J%22">Kenneth Baillie J</searchLink>; Division of Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Reynolds+RM%22">Reynolds RM</searchLink>; BHF/University Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.
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